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首页> 外文期刊>Environmental Science & Technology >In Vitro Method To Assess Soil Arsenic Metabolism by Human Gut Microbiota: Arsenic Speciation and Distribution
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In Vitro Method To Assess Soil Arsenic Metabolism by Human Gut Microbiota: Arsenic Speciation and Distribution

机译：人体肠道菌群评估土壤砷代谢的体外方法：砷的形态和分布

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摘要

Arsenic (As) speciation and distribution are two important factors in assessing human health risk from As-contaminated soil. In this study, we used the combination of physiologically based extraction test (PBET) and Simulator of Human Intestinal Microbial Ecosystem (SHIME) to determine soil As metabolism by human gut microbiota. The results showed that the percentage of soil arsenate [As(Ⅴ)] transformation reached 22.1-38.2%, while that of arsenite [As(m)] attained 66.5-92.0%; 30.1-56.4% of As(Ⅴ) transformed was attached to the soil solid phase. In comparison to sequential extraction results, almost all amorphous Fe/Al-curide-bound As was liberated in the colon phase. An X-ray absorption near-edge structure (XANES) showed that the As(Ⅲ) percentage in the soil solid phase reached 16.6-26.9% and reached 73.4% (soil 1) in the colon phase. Additionally, plenty of As(Ⅲ) and different extents of methylation were also observed in colon extraction solution. As bioaccessibiltty in the colon phase was 1.8-2.8 times that in the small intestinal phase. Our results indicated that human gut microbiota increased As bioaccessibiltty, and large amounts of As(Ⅲ) were adsorbed onto the soil solid phase as a result of microbial reduction. Determining As speciation and distribution in extraction solution and soil solid phases will allow for an accurate assessment of the risk to human health upon soil As exposure.
机译：砷的形态和分布是评估砷污染土壤对人类健康风险的两个重要因素。在这项研究中，我们结合了基于生理的提取测试（PBET）和人类肠道微生物生态系统（SHIME）模拟器，通过人类肠道微生物群确定土壤As代谢。结果表明，土壤砷[As（Ⅴ）]的转化率为22.1-38.2％，而砷酸盐[As（m）]的转化率为66.5-92.0％。 30.1-56.4％的转化为As（Ⅴ）附着在土壤固相上。与顺序提取结果相比，几乎所有无定形的Fe / Al-硫化物结合的As均在结肠相中释放。 X射线吸收近缘结构（XANES）表明，土壤固相中As（Ⅲ）的比例达到16.6-26.9％，结肠相达到73.4％（土壤1）。此外，在结肠提取液中还观察到大量As（Ⅲ）和不同程度的甲基化。结肠期的生物可及性是小肠期的1.8-2.8倍。我们的研究结果表明，人体肠道微生物群的生物吸收增加，微生物还原导致大量As（Ⅲ）被吸附到土壤固相上。确定萃取溶液和土壤固相中的砷形态和分布，可以准确评估土壤砷暴露对人体健康的风险。

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  • 来源
    《Environmental Science & Technology》 |2015年第17期|10675-10681|共7页
  • 作者

    Naiyi Yin; Zhennan Zhang; Xiaolin Cai; Huili Du; Guoxin Sun; Yanshan Cui;

  • 作者单位

    College of Resources and Environment, University of Chinese Academy of Sciences, Beijing 100049, People's Republic of China;

    College of Resources and Environment, University of Chinese Academy of Sciences, Beijing 100049, People's Republic of China;

    College of Resources and Environment, University of Chinese Academy of Sciences, Beijing 100049, People's Republic of China;

    College of Resources and Environment, University of Chinese Academy of Sciences, Beijing 100049, People's Republic of China;

    State Key Laboratory of Urban and Regional Ecology, Research Center for Eco-Environment Sciences, Chinese Academy of Sciences, Beijing 100085, People's Republic of China;

    College of Resources and Environment, University of Chinese Academy of Sciences, Beijing 100049, People's Republic of China;

  • 收录信息 美国《科学引文索引》(SCI);美国《工程索引》(EI);美国《生物学医学文摘》(MEDLINE);美国《化学文摘》(CA);
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