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首页> 外文期刊>Environmental Science & Technology >Tissue Distribution and Depuration Kinetics of Waterborne ~(14)C-labeled Light PAHs in Mummichog (Fundulus heteroclitus)
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Tissue Distribution and Depuration Kinetics of Waterborne ~(14)C-labeled Light PAHs in Mummichog (Fundulus heteroclitus)

机译：Mummichog（Fundulus heteroclitus）中水性〜（14）C标记的轻型PAHs的组织分布和净化动力学

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摘要

Light polycyclic aromatic hydrocarbons (PAHs) of petrogenic origin are commonly found in estuaries and coastal areas. Though they are known to be toxic to fish, little is known about their uptake and tissue distribution. This paper reports on the results of a study on uptake, elimination, and tissue distribution of three waterborne 14C-labeled PAHs in the mummichog, Fundulus heteroclitus, using whole-body autora-diography. After a 24 h exposure to 1 /iCi-IT1 of 14C- naphthalene, C-1-naphthol, and C-phenanthrene, fish were transferred to clean water and tissue distribution examined after 0,1,3,7,14, and 21 days of depuration. All compounds were readily accumulated by fish and were also rapidly eliminated (to,s range = 1.1 to 3.0 days). Most of the radioactivity in naphthalene- and phenanthrene-treated fish was found in gall bladder » liver > intestinal lumen. In naphthol-exposed fish, an important labeling of some brain areas was observed. Brain of naphthalene-exposed fish was also labeled after 24 h depuration, indicating that exposure to naphthalene may result in metabolite accumulation in the brain. This is the first study showing that naphthalene, naphthol, and/or unidentified metabolite(s) can accumulate in brain tissues, which may impair normal brain function.
机译：成因来源的轻质多环芳烃（PAH）通常在河口和沿海地区发现。尽管已知它们对鱼类有毒，但对其吸收和组织分布知之甚少。这篇论文报道了使用全身自传体成像技术研究了三种水溶性14C标记的PAHs在mummichog，Fundulus heteroclitus中的吸收，消除和组织分布的研究结果。将鱼暴露于14C-萘，C-1-萘酚和C-菲的1 / iCi-IT1中24小时后，将鱼转移到纯净水中，并在0、1、3、7、14和21后检查组织分布天的净化。所有化合物都容易被鱼类蓄积，并且也被迅速清除（至1.1至3.0天）。萘和菲处理过的鱼的大多数放射性发现在胆囊»肝脏>肠腔中。在暴露于萘酚的鱼中，观察到一些大脑区域的重要标记。净化24小时后，还对萘暴露的鱼类的大脑进行了标记，这表明暴露于萘可能导致代谢产物在大脑中积累。这是第一项研究，表明萘，萘酚和/或未确定的代谢物可在脑组织中蓄积，这可能会损害大脑的正常功能。

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  • 来源
    《Environmental Science & Technology》 |2011年第7期|p.2684-2690|共7页
  • 作者

    F. X. Valdez Domingos; CA Oliveira Ribeiro; E. Pelletier; C. Rouleau;

  • 作者单位

    Departamento de Biologia Celular, Universidade Federal do Parana, C.P. 19031, CEP: 81531-970 Curitiba PR, Brazil,Institut des Sciences de la Mer de Rimouski, Universite du Quebec a Rimouski, 310 allee des Ursulines Rimouski (Quebec), CanadaG5L 3A1;

    Departamento de Biologia Celular, Universidade Federal do Parana, C.P. 19031, CEP: 81531-970 Curitiba PR, Brazil;

    Institut des Sciences de la Mer de Rimouski, Universite du Quebec a Rimouski, 310 allee des Ursulines Rimouski (Quebec), CanadaG5L 3A1;

    Maurice-Lamontagne Institute Fisheries and Oceans Canada, 850 route de la mer Mont-Joli (Quebec), Canada G5H 3Z4;

  • 收录信息 美国《科学引文索引》(SCI);美国《工程索引》(EI);美国《生物学医学文摘》(MEDLINE);美国《化学文摘》(CA);
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