Linkage mapping of the locus responsible for male pseudohermaphroditism (mp) on rat chromosome 7

Kawai Y; Takeno Y; Kobayashi E; Tachibana M; Wakafuji Y; Noguchi J

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Linkage mapping of the locus responsible for male pseudohermaphroditism (mp) on rat chromosome 7

机译：大鼠染色体7上负责雄性假性双性生殖激素（mp）的基因座的连锁图谱

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TF is a mutant rat strain showing male pseudohermaphroditism controlled by an autosomal single recessive gene (mp). The affected rats show lack of Leydig cells and androgen deficiency. In this study, we performed linkage analysis using F-2 progeny of crosses between TF and BN strains to determine the chromosomal localization of the mp locus. The mp locus was mapped in a 4 cM region of the distal region of rat chromosome 7 between D7Rat3 and D7Rat115 or D7Rat94. Comparison of the linkage map with corresponding regions of the published rat genome sequence revealed several candidate genes for the mp mutation, including the Dhh, Tegt, Gdp3, and Amhr2 genes.

机译：TF是一种突变型大鼠品系，显示出由常染色体单隐性基因（mp）控制的雄性假性雌雄同体型。受影响的大鼠显示出睾丸间质细胞缺乏和雄激素缺乏。在这项研究中，我们使用TF和BN菌株之间杂交的F-2子代进行了连锁分析，以确定mp基因座的染色体定位。 mp基因座被定位在大鼠染色体7的远端区域的4cM区域中的D7Rat3和D7Rat115或D7Rat94之间。连锁图谱与已发表的大鼠基因组序列的相应区域的比较揭示了mp突变的几个候选基因，包括Dhh，Tegt，Gdp3和Amhr2基因。

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来源
《Experimental Animals》 |2004年第4期|p.379-382|共4页
作者
Kawai Y; Takeno Y; Kobayashi E; Tachibana M; Wakafuji Y; Noguchi J;
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作者单位

Kunieda T, Okayama Univ, Grad Sch Nat Sci & Technol, Okayama 7008530, Japan;

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收录信息美国《科学引文索引》(SCI);美国《生物学医学文摘》(MEDLINE);美国《化学文摘》(CA);
原文格式 PDF
正文语种 eng
中图分类动物学;
关键词
Androgen deficiency; Leydig cell; Male pseudohermaphroditism; Sex determination; Leydig-cells; Gene; Rat; Testis; Mice; Expression; Protein; Gonad;

机译：雄激素缺乏症;间质细胞;雄性假性雌雄同体;性测定;间质细胞;基因;大鼠;睾丸;小鼠;表达;蛋白质;性腺;

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Linkage mapping of the locus responsible for male pseudohermaphroditism (mp) on rat chromosome 7

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