Transcriptional Profiling of Ochratoxin-A-Induced Apoptosis in Primary Rat Hepatocytes

M. Chopra; D. Schrenk

首页> 外文期刊>Lebensmittelchemie >Transcriptional Profiling of Ochratoxin-A-Induced Apoptosis in Primary Rat Hepatocytes

【24h】

Transcriptional Profiling of Ochratoxin-A-Induced Apoptosis in Primary Rat Hepatocytes

机译：ch曲毒素A诱导的原代大鼠肝细胞凋亡的转录分析。

获取原文

获取原文并翻译 | 示例

获取外文期刊封面封底 >>

开具论文收录证明 >>

文献代查 >>

页面导航

摘要
著录项
相似文献
相关主题

摘要

The mycotoxin Ochratoxin A (OTA) is produced by one Penicillium and several Aspergillus species. The high prevalence of OTA exposure among humans worldwide has become a reason of concern because this substance causes adverse effects both in animals and in cell culture. The kidney is the main target organ affected by OTA in mammals. In humans, epidemiologicrndata indicate a correlation between OTA exposure and chronic nephrotoxicity. Fur-thermore, high exposure to OTA appears to be associated with the occurrence of tumours of the urinary tract (bladder and urothelia). Other adverse effects include genotoxicity, and hepatotoxicity. Even at very low concentrations OTA causes per-turbations of cellular signalling pathways as well as enhanced apoptosis.

机译：霉菌毒素O曲霉毒素A（OTA）由一种青霉菌和几种曲霉菌产生。在全世界的人类中，OTA暴露的高流行已成为人们关注的原因，因为该物质对动物和细胞培养均造成不利影响。肾脏是哺乳动物中受OTA影响的主要靶器官。在人类中，流行病学数据表明OTA暴露与慢性肾毒性之间存在相关性。此外，大量暴露于OTA似乎与尿路肿瘤（膀胱和尿路上皮）有关。其他不良影响包括遗传毒性和肝毒性。即使在非常低的浓度下，OTA也会引起细胞信号通路的紊乱以及细胞凋亡的增强。

著录项

来源
《Lebensmittelchemie》 |2009年第4期|99-99|共1页
作者
M. Chopra; D. Schrenk;
展开▼
作者单位

Food Chemistry and Toxicology, Univer-rnsity of Kaiserslautern;

Food Chemistry and Toxicology, Univer-rnsity of Kaiserslautern;

展开▼
收录信息
原文格式 PDF
正文语种 ger
中图分类
关键词

相似文献

外文文献
中文文献
专利

1. Transcriptional profiles induced by the Aryl Hydrocarbon Receptor agonists 2,3,7,8-tetrachlorodibenzo-p-dioxin, 2,3,7,8-tetrachlorodibenzofuran and 2,3,4,7,8-pentachlorodibenzofuran in primary rat hepatocytes [J] . J. Craig Rowlands, Robert Budinsky, Bhaskar Gollapudi, Chemosphere . 2011,第2期

机译：芳基烃受体激动剂2,3,7,8-四氯二苯并-对-二恶英，2,3,7,8-四氯二苯并呋喃和2,3,4,7,8-五氯二苯并呋喃诱导的转录特征
2. A comparative study of genome-wide transcriptional profiles of primary hepatocytes in collagen sandwich and monolayer cultures. [J] . Kim Y, Lasher CD, Milford LM, Tissue engineering, Part C. Methods . 2010,第6期

机译：胶原三明治和单层培养物中原代肝细胞全基因组转录谱的比较研究。
3. Transcription factor 7-like 2 polymorphism modulates glucose and lipid homeostasis, adipokine profile, and hepatocyte apoptosis in NASH. [J] . Musso G, Gambino R, Pacini G, Hepatology: Official Journal of the American Association for the Study of Liver Diseases . 2009,第2期

机译：转录因子7样2多态性调节NASH中的葡萄糖和脂质稳态，脂肪因子分布和肝细胞凋亡。
4. A Tryptophan Pyrolysis Product, 3-Amino-1,4- dimethyl-5H-pyrido4,3-bindole(Trp-P-1) but Not Its Metabolite Induces Apoptosis in Primary Cultured Rat Hepatocytes: Induction of CYP 1A Interfaces Trp-P-1-Induced Apoptosis [C] . Bunsyo Shiotani, Hitoshi Ashida, Yuji Nonaka, Symposium on food factors in health promotion and disease prevention . 2003

机译：色氨酸热解产物，3-氨基-1,4-二甲基-5H-吡啶4,3-B吲哚（TRP-P-1）但不是其代谢物在原发性培养大鼠肝细胞中诱导细胞凋亡：CYP 1A界面的诱导TRP-P-1诱导的细胞凋亡
5. In vitro thyroid hormone metabolism: Effects of nuclear receptor activation on the metabolic profiles of thyroxine in rat and human hepatocytes. [D] . Richardson, Vicki Michele. 2013

机译：体外甲状腺激素代谢：核受体活化对大鼠和人类肝细胞甲状腺素代谢谱的影响。
6. A Comparative Study of Genome-Wide Transcriptional Profiles of Primary Hepatocytes in Collagen Sandwich and Monolayer Cultures [O] . Yeonhee Kim, Christopher D. Lasher, Logan M. Milford, -1

机译：胶原三明治和单层培养中原代肝细胞全基因组转录谱的比较研究
7. A Comparative Study of Genome-Wide Transcriptional Profiles of Primary Hepatocytes in Collagen Sandwich and Monolayer Cultures [O] . Kim, Yeonhee, Lasher, Christopher D., Milford, Logan M., 2010

机译：胶原三明治和单层培养中原代肝细胞全基因组转录谱的比较研究

Transcriptional Profiling of Ochratoxin-A-Induced Apoptosis in Primary Rat Hepatocytes

摘要

著录项

相似文献

相关主题

期刊订阅