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首页> 外文期刊>Food Science and Biotechnology >Antihyperglycemic effect of fermented Gastrodia elata blume in streptozotocin-induced diabetic mice
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Antihyperglycemic effect of fermented Gastrodia elata blume in streptozotocin-induced diabetic mice

机译：天麻发酵液对链脲佐菌素诱导的糖尿病小鼠的降血糖作用

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摘要

Gastrodia elata Blume (GE) has been used in traditional medicine as a sedative, an anti-convulsant and anti-epileptic drug. This study was performed to investigate antihyperglycemic effect of fermented-Gastrodia elata Blume (FGE) in streptozotocin (STZ)-induced type 1 diabetic mice. FGE was prepared by fermentation with Saccharomyces cerevisia. GE and FGE were orally administered at 20 or 100 mg/kg/day for 3 weeks to STZ (70 mg/kg)-induced diabetic mice. Administartion of FGE significantly reduced blood glucose levels in an oral glucose tolerance test (OGTT), fasting blood glucose (FBG), and glycosylated hemoglobin (HbA1c) compared to GE. In addition, FGE significantly decreased serum total cholesterol (TC), triglyceride (TG), low density lipoprotein cholesterol (LDL-C) and at the same time markedly increased serum high density lipoprotein cholesterol (HDL-C) and plasma insulin levels. The results of this experimental study indicate that FGE possesses antihyperglycemic effect in STZ-induced diabetic mice.
机译：天麻蓝光（GE）已在传统医学中用作镇静剂，抗惊厥药和抗癫痫药。进行这项研究以研究发酵天麻蓝藻（FGE）在链脲佐菌素（STZ）诱导的1型糖尿病小鼠中的降血糖作用。通过与酿酒酵母发酵制备FGE。将GE和FGE以20或100 mg / kg /天的剂量口服给予STZ（70 mg / kg）诱导的糖尿病小鼠3周。与GE相比，在口服葡萄糖耐量试验（OGTT），空腹血糖（FBG）和糖基化血红蛋白（HbA1c）中，FGE的开始显着降低了血糖水平。此外，FGE显着降低了血清总胆固醇（TC），甘油三酸酯（TG），低密度脂蛋白胆固醇（LDL-C），同时显着提高了血清高密度脂蛋白胆固醇（HDL-C）和血浆胰岛素水平。该实验研究的结果表明，FGE在STZ诱导的糖尿病小鼠中具有降血糖作用。

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