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Hypolipidemic and antioxidative effects of rice bran and phytic acid in high fat-fed mice

机译：米糠和植酸对高脂饮食小鼠的降血脂和抗氧化作用

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The influence of rice bran and phytic acid on lipid metabolism and antioxidative status in high fat-fed mice was investigated. The mice were given high fat diet (HF) or high fat diet supplemented with rice bran (HF-RB) or phytic acid (HF-PA) for 7 weeks. The control mice (NC) received normal diet. The HF mice showed marked increase in body weight, total cholesterol levels, hepatic triglyceride concentration, and lipid peroxidation rate compared with NC group. Also, a significant decrease in antioxidant enzyme activities was observed in HF animals. Addition of rice bran and phytic acid in the diet counteracted this high fatinduced hyperlipidemia and oxidative stress, mainly by increasing fecal lipid excretion and regulation of antioxidant and lipogenic enzyme activities. These findings illustrate that rice bran and phytic acid possess antihyperlipidemic action and antioxidant status-improving ability, and may be beneficial as dietary supplements in the management of high fat diet-induced hyperlipidemia.
机译：研究了米糠和植酸对高脂喂养小鼠脂质代谢和抗氧化状态的影响。给小鼠高脂饮食（HF）或补充米糠（HF-RB）或植酸（HF-PA）的高脂饮食7周。对照小鼠（NC）接受正常饮食。与NC组相比，HF小鼠的体重，总胆固醇水平，肝甘油三酸酯浓度和脂质过氧化率显着增加。另外，在HF动物中观察到抗氧化酶活性的显着降低。饮食中添加米糠和植酸可抵制这种高脂肪诱导的高脂血症和氧化应激反应，这主要是通过增加粪便脂质排泄并调节抗氧化剂和脂肪酶的活性来实现的。这些发现说明米糠和植酸具有降血脂作用和抗氧化状态改善能力，并且可以作为饮食补充剂来管理高脂饮食引起的高脂血症。

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