Synthetic approaches to 1-(2-chlorophenyl)isoquinoline-3-carboxylic acid

Yves L. Janin Emmanuel Roulland Arnaud Beurdeley-Thomas Didier Decaudin Claude Monneret and Marie-France Poupon

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Synthetic approaches to 1-(2-chlorophenyl)isoquinoline-3-carboxylic acid

机译：1-（2-氯苯基）异喹啉-3-羧酸的合成方法

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In connection with our research of new antitumor compounds, previously undescribed approaches to then1-(2-chlorophenyl)isoquinoline-3-carboxylic acid 9 are reported here. Two related accesses from phenylethylaminenor amphetamine were investigated and were found to be successful. A more robust synthesis, using Suzuki’sncross-coupling between 2-chlorophenylboronic acid 15 and the previously unreported methyl-1-bromoisoquinoline-n3-carboxylate 14 was also developed. This synthetic route provides the ground for a combinatorial approach to thencore structure of new potential peripheral benzodiazepine receptor ligands.

机译：结合我们对新的抗肿瘤化合物的研究，此处报道了先前未描述的然后1-（2-氯苯基）异喹啉-3-羧酸9的方法。苯乙胺和苯丙胺的两个相关途径得到了研究，并被认为是成功的。还开发了一种更可靠的合成方法，利用Suzuki的2-氯苯基硼酸15与以前未报道的1-溴异喹啉-n3-羧酸甲酯14之间的交叉偶联。该合成途径为组合方法提供了基础，从而为新的潜在外围苯并二氮杂receptor受体配体的核心结构奠定了基础。

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《Journal of the Chemical Society, Perkin Transactions 1》 |2002年第4期|p.529-532|共4页
作者
Yves L. Janin Emmanuel Roulland Arnaud Beurdeley-Thomas Didier Decaudin Claude Monneret and Marie-France Poupon;
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a UMR 176 CNRS-Institut Curie, 26 rue d’Ulm, 75231 Paris cedex 05, Franceb UMR 147 CNRS-Institut Curie, 26 rue d’Ulm, 75231 Paris cedex 05, France;

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1. Synthetic approaches to 1-(2-chlorophenyl)isoquinoline-3-carboxylic acid [J] . Janin YL., Roulland E., Beurdeley-Thomas A., Journal of the Chemical Society, Perkin Transactions 1 . 2002,第4期

机译：1-（2-氯苯基）异喹啉-3-羧酸的合成方法
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4. A Review of Synthetic Approaches to Biodegradable Polymeric Carboxylic Acids for Detergent Applications [C] . Y. H. Paik, E. S. Simon, G. Swift American Chemical Society . 1996

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5. Palladium-Catalyzed Cross-Coupling of N-Sulfonylaziridines with Boronic Acids and Synthetic Approaches to Organic Polymer-Supported One-Dimensional Metal Wires. [D] . Duda, Megan L. 2015

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6. SURVEY AND SUMMARY: Mutagenic potentials of damaged nucleic acids produced by reactive oxygenitrogen species: approaches using synthetic oligonucleotides and nucleotides [O] . Hiroyuki Kamiya 2003

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7. Stereochemical Assignment of the threo and erythro Forms of 2-(2,6-Dimethoxyphenoxy)-1-(3,4-dimethoxyphenyl)-1,3-propanediol from X-Ray Analyses of the Synthetic Intermediates (Z)-2-(2,6-Dimethoxyphenoxy)-3-(3,4-dimethoxyphenyl)-2-propenoic Acid and threo-2-(2,6-Dimethoxyphenoxy)-3-(3,4-dimethoxyphenyl)-3-hydroxypropanoic Acid. [O] . Knut Lundquist, Rolf Stomberg, Sverker von Unge, 1987

机译：从合成中间体（Z）-2-（Z）-2-（Z）-2-（Z）-2-（Z）-2-（Z）-2-（ 2,6-二甲氧基苯氧基）-3-（3,4-二甲氧基苯基）-2-丙基甲酸和三种-2-（2,6-二甲氧基苯氧基）-3-（3,4-二甲氧基苯基）-3-羟丙酸。

Synthetic approaches to 1-(2-chlorophenyl)isoquinoline-3-carboxylic acid

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