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首页> 外文期刊>Journal of Autism and Developmental Disorders >Differential Olfactory Identification in Children with Autism and Asperger’s Disorder: A Comparative and Longitudinal Study
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Differential Olfactory Identification in Children with Autism and Asperger’s Disorder: A Comparative and Longitudinal Study

机译：自闭症和阿斯伯格氏症儿童的嗅觉鉴别：一项纵向比较研究

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摘要

Key theories of autism implicate orbitofrontal cortex (OFC) compromise, while olfactory identification (OI) deficits are associated with OFC dysfunction. This study aimed to complete a 5-year follow-up of children with high-functioning autism (HFA) who previously lacked the normal age-OI association; and compare unirhinal-OI in children with HFA, Asperger’s disorder (ASP), and controls. While both HFA and controls had improved birhinal-OI at follow-up, reduced OI in some HFA participants suggested OFC deterioration and heterogeneous OFC development. Unirhinal-OI was impaired in HFA but not ASP relative to controls, suggesting orbitofrontal compromise in HFA but integrity in ASP. Differing IQ-OI relationships existed between HFA and ASP. Findings support the hypothesis of separate neurobiological underpinnings in ASP and HFA, specifically differential orbitofrontal functioning.
机译：自闭症的主要理论牵涉到眶额皮质（OFC）的危害，而嗅觉识别（OI）缺陷与OFC功能障碍有关。这项研究的目的是对以前缺乏正常年龄OI关联的高功能自闭症（HFA）儿童进行5年随访。并比较HFA，阿斯伯格症（ASP）和对照组儿童的非irinalal-OI。尽管HFA和对照在随访中均改善了双歧杆菌OI，但某些HFA参与者的OI降低表明OFC恶化和OFC异质发展。相对于对照，Unirhinal-OI在HFA中受损，但ASP没有受损，这表明HFA的眶额受损，但ASP完整性。 HFA和ASP之间存在不同的IQ-OI关系。研究结果支持ASP和HFA中单独的神经生物学基础，特别是眼眶额叶功能差异的假说。

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  • 来源
    《Journal of Autism and Developmental Disorders》 |2011年第7期|p.837-847|共11页
  • 作者

    Tamara May; Warrick J. Brewer; Nicole J. Rinehart; Peter G. Enticott; Avril V. Brereton; Bruce J. Tonge;

  • 作者单位

    Centre for Developmental Psychiatry and Psychology, School of Psychology and Psychiatry, Monash University, Clayton, VIC, Australia;

    ORYGEN Youth Health Research Centre, University of Melbourne, Locked Bag 10, Parkville, 3052, VIC, Australia;

    Centre for Developmental Psychiatry and Psychology, School of Psychology and Psychiatry, Monash University, Notting Hill, VIC, Australia;

    Centre for Developmental Psychiatry and Psychology, School of Psychology and Psychiatry, Monash University, Clayton, VIC, Australia;

    Centre for Developmental Psychiatry and Psychology, School of Psychology and Psychiatry, Monash University, Clayton, VIC, Australia;

    Centre for Developmental Psychiatry and Psychology, School of Psychology and Psychiatry, Monash University, Clayton, VIC, Australia;

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  • 正文语种 eng
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  • 关键词

    High-functioning autism; Asperger’s disorder; Olfactory identification; UPSIT;

    机译：高功能自闭症;阿斯伯格氏症;嗅觉鉴定;UPSIT;

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