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首页> 外文期刊>Journal of Autism and Developmental Disorders >Anterior EEG Asymmetry and the Modifier Model of Autism
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Anterior EEG Asymmetry and the Modifier Model of Autism

机译：前脑电图不对称和自闭症的修正模型

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Individual differences in the expression of autism complicate research on the nature and treatment of this disorder. In the Modifier Model of Autism (Mundy et al. 2007), we proposed that individual differences in autism may result not only from syndrome specific causal processes, but also from variability in generic, non-syndrome specific modifier processes that affect the social and emotional development of all people. One study supporting this model found that measures of resting anterior EEG asymmetry, a measure reflecting complex brain processes associated with generic individual differences in approach and avoidance motivation, may help explain differences in the expression of autism in children without intellectual disabilities (Sutton et al. 2005). In the current study, we partially replicated the observation that children with autism who exhibited a pattern of left frontal EEG asymmetry tended to display milder levels of social symptoms, although in the current sample this pattern applied only to HFA children with relatively lower verbal IQs. New observations indicated that left frontal EEG asymmetry was also associated with retrospective parent reports of significantly later age of onset of symptoms, but also higher levels of self-reported outward expressions of anger as well as symptoms of obsessive compulsive disorder in school-age higher functioning children with ASD. Therefore, the results of this study provide a new and fully independent set of observations, which indicate that individual differences in anterior EEG asymmetry may significantly moderate the expression and developmental course of autism. This observation may have clinical implications for identifying meaningful diagnostic sub-groups among children with autism.
机译：自闭症表达的个体差异使对这种疾病的性质和治疗的研究复杂化。在自闭症修饰语模型（Mundy等人，2007年）中，我们提出自闭症的个体差异不仅可能是由特定于综合征的因果过程引起的，而且可能是由影响社会和情感的通用，非综合症特定修饰语过程的变异性引起的所有人的发展。支持该模型的一项研究发现，静息性前脑电图不对称性的量度可以反映出无智力障碍的儿童自闭症表达的差异（Sutton等2005年）。在本研究中，我们部分复制了观察结果，即表现出左额叶脑电图不对称模式的自闭症儿童倾向于表现出较轻的社交症状水平，尽管在当前样本中，该模式仅适用于言语智商相对较低的HFA儿童。新的观察结果表明，左额叶脑电图的不对称还与父母的回顾性报道有关，即症状发作年龄明显晚一些，但自报的愤怒外向表达水平较高，以及学龄期较高功能性强迫症症状儿童自闭症。因此，这项研究的结果提供了一套全新的，完全独立的观察结果，表明前脑电图不对称性的个体差异可能显着缓解自闭症的表达和发展过程。该发现可能对识别自闭症儿童中有意义的诊断亚组具有临床意义。

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