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How Relevant are GFAP Autoantibodies in Autism and Tourette Syndrome?

机译:GFAP自身抗体在自闭症和抽动秽语综合征中的相关性如何?

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Controversy exists over the role of autoantibodies to central nervous system antigens in autism and Tourette Syndrome. We investigated plasma autoantibody titers to glial fibrillary acidic protein (GFAP) in children with classic onset (33) and regressive onset (26) autism, controls (25, healthy age- and gender-matched) and individuals with Tourette Syndrome (24) by enzyme-linked immunosorbent assays. We found a significant difference in autoantibody titers to GFAP, not accounted for by age, between the Tourette (significantly lower) and regressive autism groups. However, no differences were found between: classic/regressive; classic/controls; classic/Tourette; regressive/controls; or controls/Tourette. Autoantibody responses against GFAP are unlikely to play a pathogenic role in autism or Tourette Syndrome.
机译:在自闭症和图雷特综合症中,针对中枢神经系统抗原的自身抗体的作用存在争议。我们调查了患有典型发作(33)和回归发作(26)自闭症,对照(25,健康的年龄和性别匹配)的儿童和患有Tourette综合征(24)的个体的血浆神经胶质纤维酸性蛋白(GFAP)自身抗体滴度。酶联免疫吸附测定。我们发现图雷特(显着较低)和回归自闭症组之间的针对GFAP的自身抗体滴度存在显着差异,但未按年龄分类。但是,没有发现以下差异:经典/回归;经典/控件;经典/旅游回归/控制;或控件/ Tourette。针对GFAP的自身抗体反应不太可能在自闭症或Tourette综合征中发挥致病作用。

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