A SHORT INTRODUCTION TO SOME RECENT PROGRESS IN PHYLOGENETIC NETWORK RECONSTRUCTION, GENOME MAPPING, GENE EXPRESSION ANALYSIS, MOLECULAR DYNAMIC SIMULATION, AND OTHER PROBLEMS IN BIOINFORMATICS

LIMSOON WONG

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A SHORT INTRODUCTION TO SOME RECENT PROGRESS IN PHYLOGENETIC NETWORK RECONSTRUCTION, GENOME MAPPING, GENE EXPRESSION ANALYSIS, MOLECULAR DYNAMIC SIMULATION, AND OTHER PROBLEMS IN BIOINFORMATICS

机译：简要介绍系统发育网络重建，基因组映射，基因表达分析，分子动力学模拟以及生物信息学中的其他问题方面的最新进展

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Phylogenetic network is a way to describe evolutionary histories that have undergonenevolutionary events such as recombination, hybridization, or horizontal genentransfer. The level, k, of a network determines how non-treelike the evolution can be,nwith level-0 networks being trees. A number of methods for constructing rootednphylogenetic network from triplets have been proposed in the past.1,2 In this issue,nGambette et al.3 discuss how to generalize these methods to construct unrootednphylogenetic network from quartets. The paper has three main contributions: (1) itngives an Oen5e1 t u0001en; nTTT time algorithm to compute the set of quartets of annetwork; (2) it shows that level-1 quartet consistency is NP-hard; and (3) given a setnQ of quartets, it shows that Oen4T time is su±cient to compute the unrooted level-1nnetwork N such that Q ?QeNT, if it exists.

机译：系统发育网络是描述经历了进化史（例如重组，杂交或水平基因转移）的进化历史的一种方法。网络的级别k决定了非树状演化的程度，而级别0的网络是树。过去，人们已经提出了许多从三联体构建根系进化网络的方法。1,2在本期中，nGambette等人3讨论了如何概括这些方法以从四重奏组构建根系进化网络。该论文有三个主要贡献：（1）对一个Oen5e1 t u0001en进行编程； nTTT时间算法，用于计算网络四方组；（2）表明1级四重奏一致性为NP-hard；（3）给出四重奏的setnQ，表明Oen4T时间足以计算无根的1级网络N，使得Q？QeNT（如果存在）。

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《Journal of Bioinformatics and Computational Biology》 |2012年第4期|p.1-3|共3页
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LIMSOON WONG;
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7. The Bioinformatics Bookshelf: Teach Yourself Computational Biology? Bioinformatics: The Machine Learning Approach By Pierre Baldi and Soren Brunak Cambridge, MA: MIT Press (1998). 351 pp. $40.00; Bioinformatics: A Practical Guide to the Analysis of Genes and Proteins Edited by Andreas D. Baxevanis and B. F. Francis Ouellette New York: Wiley-lnterscience (1998). 370 pp. $59.95; Guide to Human Genome Computing, Second Edition Edited by Martin J. Bishop San Diego, CA: Academic Press (1998). 306 pp. $69.95; Biological Sequence Analysis: Probabilistic Models of Proteins and Nucleic Acids By Richard Durbin, Sean Eddy, Anders Krogh, and Graeme Mitchison Cambridge: Cambridge University Press (1998). 356 pp. $34.95; Algorithms on Strings, Trees, and Sequences: Computer Science and Computational Biology By Dan Gusfield Cambridge: Cambridge University Press (1997). 534 pp. $59.95; Introduction to Computational Molecular Biology By Joao Setubal and Joao Meidanis Boston: PWS Publishing (1997). 296 pp. $61.95 [O] . Pickeral Oxana K, Boguski Mark S 1999

机译：生物信息学书架：自学计算生物学吗？生物信息学：机器学习方法，作者：Pierre Baldi和Soren Brunak剑桥，麻省：麻省理工学院出版社（1998）。 351页，$ 40.00；生物信息学：由Andreas D. Baxevanis和B. F. Francis Ouellette编辑的基因和蛋白质分析实用指南纽约：Wiley-Interscience（1998）。 370页，$ 59.95；《人类基因组计算指南》，第二版，由马丁·J·毕晓普（Martin J. Bishop）编辑，加利福尼亚州圣地亚哥：学术出版社（1998）。 306页，$ 69.95；生物序列分析：蛋白质和核酸的概率模型Richard Durbin，Sean Eddy，Anders Krogh和Graeme Mitchison剑桥：剑桥大学出版社（1998年）。 356页，$ 34.95；字符串，树和序列上的算法：计算机科学和计算生物学Dan Danssfield剑桥：剑桥大学出版社（1997年）。 534页，$ 59.95； Joao Setubal和Joao Meidanis Boston撰写的《计算分子生物学概论》：PWS出版（1997）。 296羽61.95美元

A SHORT INTRODUCTION TO SOME RECENT PROGRESS IN PHYLOGENETIC NETWORK RECONSTRUCTION, GENOME MAPPING, GENE EXPRESSION ANALYSIS, MOLECULAR DYNAMIC SIMULATION, AND OTHER PROBLEMS IN BIOINFORMATICS

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