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首页> 外文期刊>Journal of Biological Physics >Evaluation of poly(amidoamine) dendrimers as potential carriers of iminodiacetic derivatives using solubility studies and 2D-NOESY NMR spectroscopy
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Evaluation of poly(amidoamine) dendrimers as potential carriers of iminodiacetic derivatives using solubility studies and 2D-NOESY NMR spectroscopy

机译：使用溶解度研究和2D-NOESY NMR光谱评估聚（酰胺基胺）树状聚合物作为亚氨基二乙酸衍生物的潜在载体

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摘要

The interactions between dendrimers and different types of drugs are nowadays one of the most actively investigated areas of the pharmaceutical sciences. The interactions between dendrimers and drugs can be divided into: internal encapsulation, external electrostatic interaction, and covalent conjugation. In the present study, we investigated the potential of poly(amidoamine) (PAMAM) dendrimers for solubility of four iminodiacetic acid derivatives. We reported that PAMAM dendrimers contribute to significant solubility enhancement of iminodiacetic acid analogues. The nature of the dendrimer–drug complexes was investigated by 1H NMR and 2D-NOESY spectroscopy. The 1H NMR analysis proved that the water-soluble supramolecular structure of the complex was formed on the basis of ionic interactions between terminal amine groups of dendrimers and carboxyl groups of drug molecules, as well as internal encapsulation. The 2D-NOESY analysis revealed interactions between the primary amine groups of PAMAM dendrimers and the analogues of iminodiacetic acid. The results of solubility studies together with 1H NMR and 2D-NOESY experiments suggest that the interactions between PAMAM dendrimers of generation 1–4 and derivatives of iminodiacetic acid are based on electrostatic interactions and internal encapsulation.
机译：树枝状大分子与不同类型药物之间的相互作用是当今药物科学中最活跃的研究领域之一。树状聚合物与药物之间的相互作用可分为：内部包封，外部静电相互作用和共价结合。在本研究中，我们研究了聚（酰胺基胺）（PAMAM）树状聚合物对四种亚氨基二乙酸衍生物的溶解性的潜力。我们报道了PAMAM树状聚合物有助于亚氨基二乙酸类似物的显着溶解度提高。通过1 H NMR和2D-NOESY光谱研究了树状聚合物-药物复合物的性质。 1 H NMR分析证明该配合物的水溶性超分子结构是基于树枝状聚合物的末端胺基与药物分子的羧基之间的离子相互作用以及内部包封而形成的。 2D-NOESY分析揭示了PAMAM树状聚合物的伯胺基团与亚氨基二乙酸类似物之间的相互作用。溶解度研究的结果以及1 H NMR和2D-NOESY实验表明，第1-4代PAMAM树状大分子与亚氨基二乙酸衍生物之间的相互作用是基于静电相互作用和内部包封的。

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