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Antitumor activity and antitumor mechanism of triphenylphosphonium chitosan against liver carcinoma

机译：三苯基phosph壳聚糖对肝癌的抗肿瘤活性及抗肿瘤机制

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摘要

N-(3-Carboxypropyl) triphenylphosphonium bromide chitosan (TPPB-CS) was synthesized and characterized by FTIR, H-1 NMR spectrometer, and Zeta potential. TPPB-CS showed a selectivity-toxicity among cancer cell lines (MG-63 and HepG2 cells) and mouse embryonic fibroblast cells (NIH3T3 cells). A significant effect on inhibiting cell migration in HepG2 cells was observed in vitro, and TPPB-CS could effectively inhibit tumor growth in H22-bearing mice in vivo. Furthermore, the distribution of cell cycle, the level of reactive oxygen species (ROS), mitochondrial transmembrane potential (Delta psi(m)), the expression of tumor necrosis factor alpha (TNF-alpha), and vascular endothelial growth factor (VEGF) were examined to investigate the antitumor mechanism of TPPB-CS. The results suggested that the antitumor activity of TPPB-CS may be attributed to delay the cell cycle in S phase, alter the ROS and Delta psi(m) level, as well as regulate the TNF-alpha and VEGF secretion. TPPB-CS can become a promising anticancer drug for clinical therapy.
机译：合成了N-（3-羧丙基）三苯基溴化phosph壳聚糖（TPPB-CS），并通过FTIR，H-1 NMR光谱仪和Zeta电位进行了表征。 TPPB-CS在癌细胞系（MG-63和HepG2细胞）和小鼠胚胎成纤维细胞（NIH3T3细胞）中表现出选择性毒性。体外观察到显着抑制HepG2细胞迁移的作用，并且TPPB-CS可以有效地抑制荷H22小鼠体内的肿瘤生长。此外，细胞周期的分布，活性氧水平（ROS），线粒体跨膜电位（Delta psi（m）），肿瘤坏死因子α（TNF-alpha）和血管内皮生长因子（VEGF）的表达检查以研究TPPB-CS的抗肿瘤机制。结果表明，TPPB-CS的抗肿瘤活性可能归因于延迟S期细胞周期，改变ROS和Delta psi（m）水平以及调节TNF-α和VEGF的分泌。 TPPB-CS可以成为有希望的临床治疗抗癌药物。

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  • 来源
    《Journal of Materials Research》 |2018年第17期|2586-2597|共12页
  • 作者

    Huang Haochao; Wu Haiwei; Huang Yongrui; Zhang Shuangying; Lam Yuetwai; Ao Ningjian;

  • 作者单位

    Jinan Univ, Dept Biomed Engn, Guangzhou 510632, Guangdong, Peoples R China;

    Jinan Univ, Coll Chem & Mat Sci, Guangzhou 510632, Guangdong, Peoples R China;

    Jinan Univ, Dept Biomed Engn, Guangzhou 510632, Guangdong, Peoples R China;

    Jinan Univ, Dept Biomed Engn, Guangzhou 510632, Guangdong, Peoples R China;

    Jinan Univ, Dept Biomed Engn, Guangzhou 510632, Guangdong, Peoples R China;

    Jinan Univ, Dept Biomed Engn, Guangzhou 510632, Guangdong, Peoples R China;

  • 收录信息 美国《科学引文索引》(SCI);美国《工程索引》(EI);美国《生物学医学文摘》(MEDLINE);
  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类
  • 关键词

    triphenylphosphonium chitosan; antitumor activity and mechanism; liver carcinoma;

    机译：三苯基phosph壳聚糖;抗肿瘤活性和作用机制;肝癌;

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