• 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Journal of Materials Science. Materials in Medicine >Porous and dense poly(L-lactic acid) and poly(D,L-lactic acid-co-glycolic acid) scaffolds: In vitro degradation in culture medium and osteoblasts culture
【24h】

Porous and dense poly(L-lactic acid) and poly(D,L-lactic acid-co-glycolic acid) scaffolds: In vitro degradation in culture medium and osteoblasts culture

机译：多孔致密的聚（L-乳酸）和聚（D，L-乳酸-乙醇酸共聚物）支架：在培养基和成骨细胞培养物中的体外降解

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

The use of bioresorbable polymers as a support for culturing cells has received special attention as an alternative for the treatment of lesions and the loss of tissue. The aim of this work was to evaluate the degradation in cell culture medium of dense and porous scaffolds of poly(L-lactic acid) (PLLA) and poly(D,L-lactic acid-co-glycolic acid) (50:50) (PLGA_(50)) prepared by casting. The adhesion and morphology of osteoblast cells on the surface of these polymers was evaluated. Thermal analyses were done by differential scanning calorimetry and thermogravimetric analysis and cell morphology was assessed by scanning electron microscopy. Autocatalysis was observed in PLGA_(50) samples because of the concentration of acid constituents in this material. Samples of PLLA showed no autocatalysis and hence no changes in their morphology, indicating that this polymer can be used as a structural support. Osteoblasts showed low adhesion to PLLA compared to PLGA_(50). The cell morphology on the surface of these materials was highly dispersed, which indicated a good interaction of the cells with the polymer substrate.
机译：使用生物可吸收聚合物作为培养细胞的载体已受到特别关注，作为治疗病变和组织损失的替代方法。这项工作的目的是评估聚（L-乳酸）（PLLA）和聚（D，L-乳酸-共乙醇酸）的致密和多孔支架在细胞培养基中的降解（50:50） （PLGA_（50））通过铸造准备。评价了这些聚合物表面上成骨细胞的粘附性和形态。通过差示扫描量热法和热重分析法进行热分析，并通过扫描电子显微镜评估细胞形态。由于该材料中酸成分的浓度，在PLGA_（50）样品中观察到了自动催化作用。 PLLA样品无自动催化作用，因此其形态无变化，表明该聚合物可用作结构载体。与PLGA_（50）相比，成骨细胞对PLLA的粘附力低。这些材料表面的细胞形态高度分散，这表明细胞与聚合物底物之间具有良好的相互作用。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号