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首页> 外文期刊>Journal of Nanjing Medical University >Distribution of Endothelin- Converting Enzyme in the Heart of Human and Rat
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Distribution of Endothelin- Converting Enzyme in the Heart of Human and Rat

机译：内皮素转化酶在人和大鼠心脏中的分布

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摘要

Objective: To determine the distribution of endothelin-converting enzyme (ECE) in different parts of the heart of adult normal Chinese and Sprague-Dawley (SD) rat. Methods: The ECE mRNA was determined by semi-quantitative reverse transcription- polymerase chain reaction. ECE activity was determined by the conversion of exogenously added big endothelin-1 to endothelin-1. Results: The ECE mRNA and activity were detected in different parts of the heart. In human, the ECE expression in atria was significantly higher than those in ventricles. No significant difference was observed between left and right atrium, and among the left ventricle, right ventricle and interventricular septum. The distribution of ECE activity was consistent with that of mRNA expression. The rat had a similar pattern of distribution of either ECE mRNA expression or activity with that of human. Conclusion: ECE exists in all parts of the heart of normal Chinese and SD rat and its distribution is similar in human and rat hearts.
机译：目的：确定内皮素转化酶（ECE）在成年正常中国人和Sprague-Dawley（SD）大鼠心脏不同部位的分布。方法：采用半定量逆转录-聚合酶链反应法检测ECE mRNA。通过将外源添加的大内皮素-1转化为内皮素-1来确定ECE活性。结果：在心脏的不同部位检测到ECE mRNA和活性。在人类中，心房中的ECE表达明显高于心室中的ECE表达。在左心房和右心房之间以及左心室，右心室和心室间隔之间未观察到显着差异。 ECE活性的分布与mRNA表达的分布一致。大鼠的ECE mRNA表达或活性分布与人类相似。结论：正常人和SD大鼠心脏的所有部位都存在ECE，在人和大鼠心脏中的分布相似。

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