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首页> 外文期刊>Journal of Oleo Science >Effect of Oat and Tartary Buckwheat - Based Food on Cholesterol - Lowering and Gut Microbiota in Hypercholesterolemia Hamsters
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Effect of Oat and Tartary Buckwheat - Based Food on Cholesterol - Lowering and Gut Microbiota in Hypercholesterolemia Hamsters

机译：燕麦与荞麦面食物对高胆固醇血症仓鼠胆固醇降低和肠道微生物的影响

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摘要

The nutritional components in oat and tartary buckwheat had been assessed to have cholesterol-lowering effects. However, The effect of oat and tartary buckwheat based-food (OF) on cholesterol-lowering and gut microbiota in hypercholesterole hamsters was still limited studied because they are usually consumed in whole gran as well as after being processed. In this study, normal diets, high fat diet (HFD) with/without OF were fed to hamsters for 30 days respectively and growth parameters, metabolic parameters, and gut microbiota were investigated, respectively. It was found that OF significantly decreased plasma total cholesterol (TC) and low-density lipoprotein cholesterol (LDL-cholesterol), lowered liver TC, cholesterol ester (CE), and triglycerides (TG) concentrations, and increased fecal weight and bile acids (BA) concentrations, compared with HFD (p < 0.05). Moreover, the concentrations of acetate, propionate, butyrate and total short-chain fatty acids (SCFAs) were significantly increased in hamsters fed with OF, compared with HFD (p < 0.05). OF changed the overall structure of gut microbiota. The relative abundances of Erysipelotrichaceae, Ruminococcaceae, and Lachnospiraceae were decreased and the relative abundance of Eubacteriaceae was increased, compared with HFD. These results suggested that OF could reduce the concentrations of plasma lipid by inhibiting cholesterol absorption in liver and promoting excretions of fecal lipid and BA. And it also increased SCFAs and modulated the gut microbiota effectively to exert the hypocholesterolemic effects.
机译：已经评估了燕麦和酒荞麦的营养成分，以具有降低胆固醇的效果。然而，燕麦和荞麦荞麦面食品（OF）对高胆固醇仓仓中的胆固醇降低和肠道微生物的影响仍然有限，因为它们通常在整个GRAN和加工后消耗。在本研究中，分别进行了正常的饮食，高脂肪饮食（HFD）分别送入仓鼠30天，并研究生长参数，代谢参数和肠道微生物群。发现血浆总胆固醇（TC）和低密度脂蛋白胆固醇（LDL-胆固醇），降低的肝脏TC，胆固醇酯（CE）和甘油三酯（TG）浓度显着降低，以及增加的粪便重量和胆汁酸（ BA）浓度与HFD相比（P <0.05）。此外，与HFD相关的仓鼠含有乙酸盐，丙酸盐，丁酸酯和总短链脂肪酸（SCFA）的浓度显着增加（P <0.05）。改变了肠道微生物群的整体结构。降低红细胞素，喇菇，喇菇，喇菇和Lachnospiraceae的相对丰度，与HFD相比，促进的相对丰度增加。这些结果表明，通过抑制肝脏的胆固醇吸收并促进粪便脂质和BA的排泄，可以降低血浆脂质的浓度。它还增加了SCFA并有效地调节了肠道微生物群，以施加次粒溶解症效应。

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  • 来源
    《Journal of Oleo Science》 |2019年第3期|251-259|共9页
  • 作者

    Nian-Xia Sun; Li-Tao Tong; Ting-Ting Liang; Li-Li Wang; Li-Ya Liu; Xian-Rong Zhou; Su-Mei Zhou;

  • 作者单位

    Institute of Food Science and Technology Chinese Academy of Agricultural Sciences/Key Laboratory of Agro-Products Processing Ministry of Agriculture Beijing 100193 CHINA;

    Institute of Food Science and Technology Chinese Academy of Agricultural Sciences/Key Laboratory of Agro-Products Processing Ministry of Agriculture Beijing 100193 CHINA;

    School of Food and Biological Engineering Shanxi University of Science and Technology Xi an 710021 CHINA;

    Institute of Food Science and Technology Chinese Academy of Agricultural Sciences/Key Laboratory of Agro-Products Processing Ministry of Agriculture Beijing 100193 CHINA;

    Institute of Food Science and Technology Chinese Academy of Agricultural Sciences/Key Laboratory of Agro-Products Processing Ministry of Agriculture Beijing 100193 CHINA;

    Institute of Food Science and Technology Chinese Academy of Agricultural Sciences/Key Laboratory of Agro-Products Processing Ministry of Agriculture Beijing 100193 CHINA;

    Institute of Food Science and Technology Chinese Academy of Agricultural Sciences/Key Laboratory of Agro-Products Processing Ministry of Agriculture Beijing 100193 CHINA;

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  • 关键词

    oat and tartary buckwheat-based food; cholesterol-lowering; gut microbiota; short-chain fatty acid;

    机译：燕麦和鞑靼荞麦食物;胆固醇降低;gut microbiota;短链脂肪酸;

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