Expression of P23 of Cryptosporidium parvum in Toxoplasma gondii and Evaluation of its Protective Effects

Hiroaki Shirafujia Xuenan Xuanab Isao Kimataac Yasuhiro Takashimaad Shinya Fukumotoa Haruki Otsukaa Hideyuki Nagasawaa and Hiroshi Suzukia

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Expression of P23 of Cryptosporidium parvum in Toxoplasma gondii and Evaluation of its Protective Effects

机译：弓形虫小隐孢子虫P23的表达及其保护作用的评价

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In this study, P23 of Cryptosporidium parvum sporozoites, an immunodominant surface protein, was stably expressed in Toxoplasma gondii (Tg/P23) and its protective effects were evaluated in a mouse model. The molecular weight and antigenic property of P23 expressed by Tg/P23 were similar to those of the native P23. Mice immunized with lysed Tg/P23 tachyzoites produced specific neutralizing antibodies against C. parvum. These findings indicate that the T. gondii vector may provide a new tool for the production of a recombinant vaccine against cryptosporidiosis in animals.

机译：在这项研究中，小球隐孢子虫子孢子的P23（一种免疫优势表面蛋白）在弓形虫（Tg / P23）中稳定表达，并在小鼠模型中评估了其保护作用。由Tg / P23表达的P23的分子量和抗原性质与天然P23相似。用裂解的Tg / P23速殖子免疫的小鼠产生了针对小球藻的特异性中和抗体。这些发现表明，刚地弓形虫载体可以为生产抗动物隐孢子虫病的重组疫苗提供新的工具。

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《Journal of Parasitology》 |2005年第2期|p.00000476-00000479|共4页
作者
Hiroaki Shirafujia Xuenan Xuanab Isao Kimataac Yasuhiro Takashimaad Shinya Fukumotoa Haruki Otsukaa Hideyuki Nagasawaa and Hiroshi Suzukia;
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aNational Research Center for Protozoan Diseases, Obihiro University of Agriculture and Veterinary Medicine, Inada-cho, Obihiro, Hokkaido 080-8555, Japan bTo whom correspondence should be addressed cDepartment of Medical Zoology, Faculty of Medicine, Osaka City University, Abeno-ku, Osaka 545-8585, Japan dDepartment of Global Agricultural Science, Graduate School of Agriculture and Life Science, The University of Tokyo, Bunkyo-ku, Tokyo, Japan. gen@obihiro.ac.jp;

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1. Evaluation of four RNA extraction methods for gene expression analyses of Cryptosporidium parvum and Toxoplasma gondii oocysts. [J] . See M. J, Staggs S. E, Dubey J. P, Journal of Microbiological Methods . 2012,第3期

机译：评价四种RNA提取方法对小隐孢子虫和弓形虫卵囊基因表达的分析。
2. Comparative evaluation of UNEX-based DNA extraction for molecular detection of Cyclospora cayetanensis, Toxoplasma gondii, and Cryptosporidium parvum as contaminants of berries [J] . Tamirat Tefera Temesgen, Alessandra Barlaam, Kristoffer R. Tysnes, Food microbiology . 2020,第Auga期

机译：基于UNEX的DNA提取技术对作为果实污染物的环孢菌，弓形虫和小隐孢子虫的分子检测的比较评估
3. Novel acyl carbamates and acyl / diacyl ureas show in vitro efficacy against Toxoplasma gondii and Cryptosporidium parvum [J] . Kun Li, Gregory M. Grooms, Shahbaz M. Khan, International Journal for Parasitology: Drugs and Drug Resistance . 2020,第3期

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4. Optical microscopy and autofluorescence recognition of Taxoplasma gondii and Cryptosporidium parvum oocysts [C] . Alejandra Alba, Laura Baker, Graciela Juez Latin American Congress on Biomedical Engineering . 2017

机译：光学显微镜和荧光识别弓形虫和脊柱孢菌卵囊
5. The Unique Glycoproteins of Cryptosporidium Parvum and Toxoplasma Gondii [D] . Haserick, John Robert 2017

机译：隐孢子虫和弓形虫的独特糖蛋白
6. Stable expression of Cryptosporidium parvum glycoprotein gp40/15 in Toxoplasma gondii [O] . Roberta M. O’Connor, Jane Wanyiri, Boguslaw Wojczyk, -1

机译：小球隐孢子虫糖蛋白gp40 / 15在弓形虫中的稳定表达
7. Stable expression of Cryptosporidium parvum glycoprotein gp40/15 in Toxoplasma gondii [O] . Roberta M. O’Connor, Jane W. Wanyiri, Boguslaw S. Wojczyk, 2007

机译：CryptoSporidium parvum糖蛋白GP40 / 15在弓形虫的稳定表达

Expression of P23 of Cryptosporidium parvum in Toxoplasma gondii and Evaluation of its Protective Effects

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