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首页> 外文期刊>Journal of Pediatric Psychology >The Impact on Health-Related Quality of Life from Non-Steroidal Anti-Inflammatory Drugs, Methotrexate, or Steroids in Treatment for Juvenile Idiopathic Arthritis
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The Impact on Health-Related Quality of Life from Non-Steroidal Anti-Inflammatory Drugs, Methotrexate, or Steroids in Treatment for Juvenile Idiopathic Arthritis

机译：非甾体类抗炎药，甲氨蝶呤或类固醇对青少年特发性关节炎的治疗对健康相关生活质量的影响

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摘要

Objective To assess and compare the impact of medication treatments on health-related quality of life (HRQOL), family function, and medical status in children with juvenile idiopathic arthritis (JIA). Methods Fifty-seven children diagnosed with JIA were assessed by a pediatric rheumatologist and placed into one of three treatment groups: (1) non-steroidal anti-inflammatory; (2) methotrexate; or (3) steroids via IV methylprednisolone. Questionnaires were administered at baseline and 4-month follow-up. The attending pediatric rheumatologist provided additional medical information. Results Data document the impact of JIA on HRQOL, particularly on physical and pain domains. Steroid patients experienced improved HRQOL at follow-up relative to other groups, despite reporting more problems with side effects. Conclusion These results demonstrate positive benefits of steroids in treating JIA children, despite the greatest incidence of adverse side effects.
机译：目的评估和比较药物治疗对青少年特发性关节炎（JIA）儿童健康相关的生活质量（HRQOL），家庭功能和医疗状况的影响。方法由小儿风湿病医师对57例经确诊为JIA的儿童进行评估，并将其分为以下三个治疗组之一：（1）非甾体类抗炎药； （2）甲氨蝶呤； （3）类固醇通过静脉注射甲基泼尼松龙。在基线和4个月的随访中进行问卷调查。主治小儿风湿病医生提供了其他医疗信息。结果数据记录了JIA对HRQOL的影响，特别是对身体和疼痛领域的影响。尽管报告了更多副作用，但类固醇患者在随访中的HRQOL有所改善。结论这些结果表明，尽管不良副作用的发生率最高，但类固醇可以有效治疗JIA儿童。

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