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Thrombospondin-1 in Patients with Diabetic Nephropathy

机译：糖尿病肾病患者的血小板反应蛋白-1

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Thrombospondin-1 (TSP-1), a potent antiangiogenic and proatherogenic protein, has been implicated in the development of several vascular diabetic complications. The aim of the study is to find the role of TSP-1 in diabetic nephropathy. We investigated serum TSP-1 in 30 patients with type 2 diabetes mellitus and diabetic nephropathy (group 1) with renal disease grade 1 to 3 (Kidney Disease Outcomes Quality Initiative stages of kidney disease) and 15 normal control subjects (group 2). Thorough history and clinical examination, biochemical tests including renal function tests, renal ultrasound and renal artery Doppler were done to the studied groups. In addition, carotid intima media thickness and serum TSP-1 enzyme-linked immunosorbent assay were measured. Serum TSP-1 was increased in diabetic nephropathy (193.33 ± 43.28) ng/ml compared to controls (106.27 ± 38.80) ng/ml (p < 0.001). TSP-1 correlates negatively with glomerular filtration rate (p < 0.001) and positively with resistivity index (RI) of extrarenal vessels (p < 0.001) and RI intrarenal vessels (p < 0.001). There is also positive correlation between serum TSP-1 with age (p = 0.004) and carotid intima media thickness (p = 0.004). No correlation was found with proteinuria (p = 0.37). Linear regression test in group 1 shows TSP-1 is significant independent determinant for glomerular filtration rate (p < 0.001) and carotid intima media thickness (p = 0.002). The present study suggests that TSP-1 plays an important role in development of complications in Patients with diabetic nephropathy. Serum level of TSP-1 is related to renal injury and vascular disease. Further studies may be necessary to determine casual relationship between TSP-1 and renal damage and to determine the role of targeting TSP-1 in managing these complications and preventing its progress.
机译：血小板反应蛋白-1（TSP-1）是一种有效的抗血管生成和促动脉粥样硬化蛋白，与多种血管性糖尿病并发症的发生有关。该研究的目的是发现TSP-1在糖尿病性肾病中的作用。我们调查了30名患有1至3级肾脏疾病（肾脏疾病的结果质量倡议阶段）的2型糖尿病和糖尿病肾病（1组）的血清TSP-1和15名正常对照受试者（2组）的血清TSP-1。彻底的病史和临​​床检查，对研究组进行了包括肾功能检查，肾脏超声检查和肾动脉多普勒检查在内的生化检查。另外，测量颈动脉内膜中层厚度和血清TSP-1酶联免疫吸附测定。与对照组（106.27±38.80）ng / ml相比，糖尿病肾病患者的血清TSP-1升高（193.33±43.28）ng / ml（p <0.001）。 TSP-1与肾小球滤过率呈负相关（p <0.001），与肾外血管（p <0.001）和RI肾内血管的电阻率指数（RI）呈正相关。血清TSP-1与年龄（p = 0.004）和颈动脉内膜中层厚度（p = 0.004）之间也呈正相关。未发现与蛋白尿相关（p = 0.37）。第1组的线性回归测试显示，TSP-1是肾小球滤过率（p <0.001）和颈动脉内膜中层厚度（p = 0.002）的重要独立决定因素。本研究表明，TSP-1在糖尿病肾病患者并发症的发生中起重要作用。血清TSP-1水平与肾脏损伤和血管疾病有关。可能需要进一步的研究来确定TSP-1与肾脏损害之间的偶然关系，并确定靶向TSP-1在处理这些并发症和预防其进展中的作用。

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