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IL-1R8 is a checkpoint in NK cells regulating anti-tumour and anti-viral activity

机译：IL-1R8是NK细胞中调节抗肿瘤和抗病毒活性的检查点

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摘要

Interleukin-1 receptor 8 (IL-1R8, also known as single immunoglobulin IL-1R-related receptor, SIGIRR, or TIR8) is a member of the IL-1 receptor (ILR) family with distinct structural and functional characteristics, acting as a negative regulator of ILR and Toll-like receptor (TLR) downstream signalling pathways and inflammation(1). Natural killer (NK) cells are innate lymphoid cells which mediate resistance against pathogens and contribute to the activation and orientation of adaptive immune responses(2-4). NK cells mediate resistance against haematopoietic neoplasms but are generally considered to play a minor role in solid tumour carcinogenesis(5-7). Here we report that IL-1R8 serves as a checkpoint for NK cell maturation and effector function. Its genetic blockade unleashes NK-cell-mediated resistance to hepatic carcinogenesis, haematogenous liver and lung metastasis, and cytomegalovirus infection.
机译：白介素-1受体8（IL-1R8，也称为单一免疫球蛋白IL-1R相关受体，SIGIRR或TIR8）是IL-1受体（ILR）家族的成员，具有独特的结构和功能特征，可作为ILR和Toll样受体（TLR）下游信号通路的负调控因子与炎症反应（1）。天然杀伤（NK）细胞是先天性淋巴样细胞，介导对病原体的抗性并有助于适应性免疫反应的激活和定向（2-4）。 NK细胞介导对造血肿瘤的抗性，但通常被认为在实体肿瘤的致癌作用中起次要作用（5-7）。在这里我们报告IL-1R8作为NK细胞成熟和效应功能的检查点。它的遗传封锁释放了NK细胞介导的对肝癌发生，血源性肝和肺转移以及巨细胞病毒感染的抗性。

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  • 来源
    《Nature》 |2017年第7678期|110-114|共5页
  • 作者

    Molgora Martina; Bonavita Eduardo; Ponzetta Andrea; Riva Federica; Barbagallo Marialuisa; Jaillon Sebastien; Popovic Branka; Bernardini Giovanni; Magrini Elena; Gianni Francesca; Zelenay Santiago; Jonjic Stipan; Santoni Angela; Garlanda Cecilia; Mantovani Alberto;

  • 作者单位

    Humanitas Clin & Res Ctr, I-20089 Rozzano, Italy;

    Humanitas Clin & Res Ctr, I-20089 Rozzano, Italy|Univ Manchester, Canc Res UK Manchester Inst, Manchester M20 4QL, Lancs, England;

    Humanitas Clin & Res Ctr, I-20089 Rozzano, Italy;

    Univ Milan, Dept Anim Pathol, Fac Vet Med, I-20133 Milan, Italy;

    Humanitas Clin & Res Ctr, I-20089 Rozzano, Italy;

    Humanitas Clin & Res Ctr, I-20089 Rozzano, Italy|Humanitas Univ, Dept Biomed Sci, I-20090 Pieve Emanuele Milan, Italy;

    Univ Rijeka, Fac Med, Rijeka 51000, Croatia;

    Univ Roma La Sapienza, Ist Pasteur, Dipartimento Med Mol, Fdn Cenci Bolognetti, I-00161 Rome, Italy|IRCCS Neuromed, I-86077 Pozzilli, IS, Italy;

    Humanitas Clin & Res Ctr, I-20089 Rozzano, Italy;

    Humanitas Clin & Res Ctr, I-20089 Rozzano, Italy;

    Univ Manchester, Canc Res UK Manchester Inst, Manchester M20 4QL, Lancs, England;

    Univ Rijeka, Fac Med, Rijeka 51000, Croatia;

    Univ Roma La Sapienza, Ist Pasteur, Dipartimento Med Mol, Fdn Cenci Bolognetti, I-00161 Rome, Italy|IRCCS Neuromed, I-86077 Pozzilli, IS, Italy;

    Humanitas Clin & Res Ctr, I-20089 Rozzano, Italy|Humanitas Univ, Dept Biomed Sci, I-20090 Pieve Emanuele Milan, Italy;

    Humanitas Clin & Res Ctr, I-20089 Rozzano, Italy|Humanitas Univ, Dept Biomed Sci, I-20090 Pieve Emanuele Milan, Italy|Queen Mary Univ London, William Harvey Res Inst, London EC1M 6BQ, England;

  • 收录信息 美国《科学引文索引》(SCI);美国《工程索引》(EI);美国《生物学医学文摘》(MEDLINE);美国《化学文摘》(CA);
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