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Differential responses to lithium in hyperexcitable neurons fromn patients with bipolar disorder

机译:躁郁症患者高兴奋性神经元对锂的差异反应

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摘要

Bipolar disorder is a complex neuropsychiatric disorder that is characterized by intermittent episodes of mania and depression; without treatment, 15% of patients commit suicide(1). Hence, it has been ranked by the World Health Organization as a top disorder of morbidity and lost productivity(2). Previous neuropathological studies have revealed a series of alterations in the brains of patients with bipolar disorder or animal models', such as reduced glial cell number in the prefrontal cortex of
机译:躁郁症是一种复杂的神经精神疾病,其特征是间歇性躁狂和抑郁发作。未经治疗的患者中有15%自杀(1)。因此,它已被世界卫生组织(WHO)列为发病率和生产力下降的顶级疾病(2)。先前的神经病理学研究表明,患有双相情感障碍或动物模型的患者的大脑发生了一系列改变,例如减少了前额叶皮层中神经胶质细胞的数量。

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  • 来源
    《Nature》 |2015年第7576期|95-99|共5页
  • 作者单位

    Salk Inst Biol Studies, Genet Lab, La Jolla, CA 92037 USA.;

    Salk Inst Biol Studies, Genet Lab, La Jolla, CA 92037 USA.;

    Salk Inst Biol Studies, Genet Lab, La Jolla, CA 92037 USA.;

    Tsinghua Univ, Sch Life Sci, McGovern Inst Brain Res, State Key Lab Membrane Biol,Tsinghua Peking Joint, Beijing 100084, Peoples R China.;

    Tsinghua Univ, Sch Life Sci, McGovern Inst Brain Res, State Key Lab Membrane Biol,Tsinghua Peking Joint, Beijing 100084, Peoples R China.;

    Salk Inst Biol Studies, Stem Cell Core, La Jolla, CA 92037 USA.;

    Chinese Acad Sci, Beijing Inst Genom, Key Lab Genom & Precis Med, Beijing 100101, Peoples R China.;

    Salk Inst Biol Studies, Genet Lab, La Jolla, CA 92037 USA.;

    Salk Inst Biol Studies, Genet Lab, La Jolla, CA 92037 USA.;

    Salk Inst Biol Studies, Genet Lab, La Jolla, CA 92037 USA.;

    Salk Inst Biol Studies, Genet Lab, La Jolla, CA 92037 USA.;

    Salk Inst Biol Studies, Genet Lab, La Jolla, CA 92037 USA.;

    Indiana Univ, Dept Psychiat, Indianapolis, IN 46202 USA.;

    Case Western Reserve Univ, Dept Psychiat, Cleveland, OH 44106 USA.;

    Univ Bergen, Dept Psychiat, N-5020 Bergen, Norway.;

    Univ Calif San Diego, Dept Psychiat, La Jolla, CA 92093 USA.;

    Johns Hopkins Univ, Dept Psychiat, Baltimore, MD 21218 USA.;

    Dalhousie Univ, Dept Psychiat, Halifax, NS B3H 2E2, Canada.;

    Univ Calif San Diego, Dept Psychiat, La Jolla, CA 92093 USA.;

    Chinese Acad Sci, Beijing Inst Genom, Key Lab Genom & Precis Med, Beijing 100101, Peoples R China.;

    Mt Sinai Sch Med, Dept Psychiat, New York, NY 10029 USA.;

    Univ Calif San Diego, Dept Psychiat, La Jolla, CA 92093 USA.;

    Salk Inst Biol Studies, Genet Lab, La Jolla, CA 92037 USA.;

    Jiangsu Normal Univ, Jiangsu Collaborat Innovat Ctr Language Abil, Xuzhou 221009, Peoples R China.;

    Salk Inst Biol Studies, Genet Lab, La Jolla, CA 92037 USA.;

    Tsinghua Univ, Sch Life Sci, McGovern Inst Brain Res, State Key Lab Membrane Biol,Tsinghua Peking Joint, Beijing 100084, Peoples R China.;

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