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首页> 外文期刊>Nature >Antigen-specific B-cell receptor sensitizes B cells to infection by influenza virus
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Antigen-specific B-cell receptor sensitizes B cells to infection by influenza virus

机译：抗原特异性B细胞受体可使B细胞对流感病毒感染敏感

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摘要

Influenza A virus-specific B lymphocytes and the antibodies they produce protect against infection. However, the outcome of interactions between an influenza haemagglutinin-specific B cell via its receptor (BCR) and virus is unclear. Through somatic cell nuclear transfer we generated mice that harbour B cells with a BCR specific for the haemagglutinin of influenza A/WSN/33 virus (FluBI mice). Their B cells secrete an immunoglobulin gamma 2b that neutralizes infectious virus. Whereas B cells from FluBI and control mice bind equivalent amounts of virus through interaction of haemagglutinin with surface-disposed sialic acids, the A/WSN/33 virus infects only the haemagglutinin-specific B cells. Mere binding of virus is not sufficient for infection of B cells: this requires interactions of the BCR with haemagglutinin, causing both disruption of antibody secretion and FluBI B-cell death within 18 h. In mice infected with A/WSN/33, lung-resident FluBI B cells are infected by the virus, thus delaying the onset of protective antibody release into the lungs, whereas FluBI cells in the draining lymph node are not infected and proliferate. We propose that influenza targets and kills influenza-specific B cells in the lung, thus allowing the virus to gain purchase before the initiation of an effective adaptive response.
机译：甲型流感病毒特异性B淋巴细胞及其产生的抗体可防止感染。但是，尚不清楚流感血凝素特异性B细胞通过其受体（BCR）与病毒之间相互作用的结果。通过体细胞核转移，我们生成了带有BCR细胞的小鼠（FluBI小鼠），其中B细胞具有针对A / WSN / 33流感病毒血凝素的BCR特异性。他们的B细胞分泌一种中和传染性病毒的免疫球蛋白γ2b。 FluBI和对照小鼠的B细胞通过血凝素与表面唾液酸的相互作用结合了等量的病毒，而A / WSN / 33病毒仅感染血凝素特异性B细胞。仅仅结合病毒不足以感染B细胞：这需要BCR与血凝素相互作用，从而导致抗体分泌中断和FluBI B细胞在18小时内死亡。在感染了A / WSN / 33的小鼠中，肺部驻留的FluBI B细胞被病毒感染，从而延迟了保护性抗体向肺部释放的开始，而引流淋巴结中的FluBI细胞未被感染并增殖。我们建议流感病毒靶向并杀死肺中的流感病毒特异性B细胞，从而使病毒能够在有效的适应性反应启动之前获得购买。

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  • 来源
    《Nature》 |2013年第7476期|406-409|共4页
  • 作者

    Stephanie K. Dougan; Joseph Ashour; Roos A. Karssemeijer; Maximilian W. Popp; Ana M. Avalos; Marta Barisa; Arwen F. Altenburg; Jessica R. Ingram; Juan Jose Cragnolini; Chunguang Guo; Frederick W. Alt; Rudolf Jaenisch; Hidde L. Ploegh;

  • 作者单位

    Whitehead Institute tor Biomedical Research, 9 Cambridge Center, Cambridge, Massachusetts 02142, USA;

    Whitehead Institute tor Biomedical Research, 9 Cambridge Center, Cambridge, Massachusetts 02142, USA;

    Whitehead Institute tor Biomedical Research, 9 Cambridge Center, Cambridge, Massachusetts 02142, USA;

    Whitehead Institute tor Biomedical Research, 9 Cambridge Center, Cambridge, Massachusetts 02142, USA,Department of Biology, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, USA;

    Whitehead Institute tor Biomedical Research, 9 Cambridge Center, Cambridge, Massachusetts 02142, USA;

    Whitehead Institute tor Biomedical Research, 9 Cambridge Center, Cambridge, Massachusetts 02142, USA;

    Whitehead Institute tor Biomedical Research, 9 Cambridge Center, Cambridge, Massachusetts 02142, USA;

    Whitehead Institute tor Biomedical Research, 9 Cambridge Center, Cambridge, Massachusetts 02142, USA;

    Whitehead Institute tor Biomedical Research, 9 Cambridge Center, Cambridge, Massachusetts 02142, USA;

    Boston Children's Hospital, Karp Family Research Building, One Blackfan Circle Boston, Massachusetts 02115, USA;

    Boston Children's Hospital, Karp Family Research Building, One Blackfan Circle Boston, Massachusetts 02115, USA;

    Whitehead Institute tor Biomedical Research, 9 Cambridge Center, Cambridge, Massachusetts 02142, USA;

    Whitehead Institute tor Biomedical Research, 9 Cambridge Center, Cambridge, Massachusetts 02142, USA,Department of Biology, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, USA;

  • 收录信息 美国《科学引文索引》(SCI);美国《工程索引》(EI);美国《生物学医学文摘》(MEDLINE);美国《化学文摘》(CA);
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