Recent progress in the biology and physiology of sirtuins

Toren Finkel; Chu-Xia Deng; Raul Mostoslavsky

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Recent progress in the biology and physiology of sirtuins

机译：sirtuins生物学和生理学的最新进展

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The sirtuins are a highly conserved family of NAD~+-dependent enzymes that regulate lifespan in lower organisms. Recently, the mammalian sirtuins have been connected to an ever widening circle of activities that encompass cellular stress resistance, genomic stability, tumorigenesis and energy metabolism. Here we review the recent progress in sirtuin biology, the role these proteins have in various age-related diseases and the tantalizing notion that the activity of this family of enzymes somehow regulates how long we live.

机译：sirtuins是一个高度保守的NAD〜+依赖性酶家族，可调节下层生物的寿命。近来，哺乳动物的sirtuins已经与包括细胞抗应激，基因组稳定性，肿瘤发生和能量代谢在内的不断扩大的活动联系在一起。在这里，我们回顾了瑟土因生物学的最新进展，这些蛋白质在各种与年龄有关的疾病中的作用以及令人信服的观念，即该酶家族的活性以某种方式调节了我们的寿命。

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《Nature》 |2009年第7255期|587-591|共5页
作者
Toren Finkel; Chu-Xia Deng; Raul Mostoslavsky;
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作者单位

Translational Medicine Branch, National Heart Lung and Blood Institute, US National Institutes of Health, Bethesda, Maryland 20892, USA;

Genetics of Development and Disease Branch, National Institute of Diabetes, Digestive and Kidney Diseases, US National Institutes of Health, Bethesda, Maryland 20892, USA;

The Massachusetts General Hospital Cancer Center, Harvard Medical School, Boston, Massachusetts 02114, USA;

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收录信息美国《科学引文索引》(SCI);美国《工程索引》(EI);美国《生物学医学文摘》(MEDLINE);美国《化学文摘》(CA);
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6. Recent progress in the biology and physiology of sirtuins [O] . Toren Finkel, Chu-Xia Deng, Raul Mostoslavsky -1

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7. Sirtuins in gamete biology and reproductive physiology: emerging roles and therapeutic potential in female and male infertility [O] . Carla Tatone, Giovanna Di Emidio, Arcangelo Barbonetti, 2018

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Recent progress in the biology and physiology of sirtuins

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