A bad boy comes good

Ulrich Theopold

摘要

Few concepts have been embraced by popular science as enthusiastically as the idea that reactive oxygen species (ROS) are harmful and that their levels should be controlled by including antioxidants in the diet or as supplements. Despite this 'bad boy' reputation, ROS have important roles in immune defence. They act as potent effector molecules that can kill unwanted intruders, and as intra-cellular messengers that help to regulate immune responses. On page 537 of this issue, Owusu-Ansah and Banerjee1 demonstrate an additional function for ROS by showing that they are crucial for the early development of immune cells during the process of blood-cell formation, or haematopoiesis.rnThe organism providing this insight is the fruitfly Drosophila melanogaster, a well-established model system for studying humoral innate immunity - immunity mediated by secreted compounds - but a comparative newcomer to the study of cellular immunity. Drosophila's immune cells come in three classes: plasmatocytes and crystal cells, which are present in uninfected animals, and lamellocytes, which occur mostly in infected animals, where they form capsules around foreign bodies.

机译：很少有概念被流行科学如此热情地认为是活性氧（ROS）是有害的，应通过在饮食中或作为补充剂加入抗氧化剂来控制其含量。尽管享有“坏男孩”的美誉，但ROS在免疫防御中仍发挥着重要作用。它们充当可杀死不需要的入侵者的有效效应分子，并充当有助于调节免疫反应的细胞内信使。在该期杂志的第537页上，Owusu-Ansah和Banerjee1通过证明它们对于血细胞形成或造血过程中免疫细胞的早期发育至关重要，证明了ROS的附加功能。果蝇果蝇（Drosophila melanogaster），一种成熟的用于研究体液先天免疫（由分泌化合物介导的免疫）的模型系统，但是细胞免疫研究的比较新手。果蝇的免疫细胞分为三类：未感染动物中存在的浆细胞和晶状体细胞，以及大多数在感染动物中存在的层状细胞，它们在异物周围形成胶囊。

A bad boy comes good

摘要

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