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Mechanism of action of interferon and ribavirin in treatment of hepatitis C

机译:干扰素和病毒唑治疗丙型肝炎的作用机理

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Since the identification of the hepatitis C virus, great strides have been made in the development of an antiviral therapy. As a crucial mediator of the innate antiviral immune response, interferon-alpha (IFN-alpha) was a natural choice for treatment. Whereas treatment with IFN-alpha alone achieved only modest success, the addition of the broad-spectrum antiviral agent ribavirin greatly improved responses. However, half of the infected individuals with chronic disease do not achieve sustained clearance of hepatitis C virus. To optimize current therapeutic strategies and to develop new therapies, a better understanding of the mechanism of action of IFN and ribavirin will be essential.
机译:自从鉴定出丙型肝炎病毒以来,抗病毒治疗的发展已取得了长足的进步。作为先天性抗病毒免疫反应的重要介质,干扰素-α(IFN-α)是治疗的自然选择。单独用IFN-α治疗仅取得了一定程度的成功,而加入广谱抗病毒药物利巴韦林则大大改善了反应。但是,一半的慢性病感染者无法持续清除丙型肝炎病毒。为了优化当前的治疗策略并开发新的疗法,对IFN和利巴韦林的作用机理有更好的了解将是必不可少的。

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