The DNA sequence and analysis of human chromosome 14

Roland Heilig; Ralph Eckenberg; Jean-Louis Petit; Nurfa Fonknechten; Corinne Da Silva; Laurence Cattolico; Michaeel Levy; Valerie Barbe; Veronique de Berardinis; Abel Ureta-Vidal; Eric Pelletier; Virginie Vico; Veronique Anthouard; Lee Rowen; Anup Madan

首页> 外文期刊>Nature >The DNA sequence and analysis of human chromosome 14

【24h】

The DNA sequence and analysis of human chromosome 14

机译：人类14号染色体的DNA序列和分析

获取原文

获取原文并翻译 | 示例

掌桥外文数据库（机构版） >>

开具论文收录证明 >>

文献代查 >>

页面导航

摘要
著录项
相似文献
相关主题

摘要

Chromosome 14 is one of five acrocentric chromosomes in the human genome. These chromosomes are characterized by a heterochromatic short arm that contains essentially ribosomal RNA genes, and a euchromatic long arm in which most, if not all, of the protein-coding genes are located. The finished sequence of human chromosome 14 comprises 87,410,661 base pairs, representing 100% of its euchromatic portion, in a single continuous segment covering the entire long arm with no gaps. Two loci of crucial importance for the immune system, as well as more than 60 disease genes, have been localized so far on chromosome 14. We identified 1,050 genes and gene fragments, and 393 pseudogenes. On the basis of comparisons with other vertebrate genomes, we estimate that more than 96% of the chromosome 14 genes have been annotated. From an analysis of the CpG island occurrences, we estimate that 70% of these annotated genes are complete at their 5′ end.

机译：14号染色体是人类基因组中的五个Acrocentric染色体之一。这些染色体的特征是具有基本上包含核糖体RNA基因的异色短臂和常染色体的长臂，其中大部分（即使不是全部）蛋白质编码基因也位于其中。人类染色体14的最终序列包含87,410,661个碱基对，代表其常染色体部分的100％，位于一个连续的片段中，覆盖了整个长臂且没有任何间隙。到目前为止，两个对免疫系统至关重要的基因座以及60多个疾病基因已经定位在14号染色体上。我们鉴定了1,050个基因和基因片段以及393个假基因。在与其他脊椎动物基因组进行比较的基础上，我们估计已注释了96％以上的14号染色体基因。通过对CpG岛出现的分析，我们估计这些带注释的基因中有70％在其5'末端完整。

著录项

来源
《Nature》 |2003年第6923期|p.601-607|共7页
作者
Roland Heilig; Ralph Eckenberg; Jean-Louis Petit; Nurfa Fonknechten; Corinne Da Silva; Laurence Cattolico; Michaeel Levy; Valerie Barbe; Veronique de Berardinis; Abel Ureta-Vidal; Eric Pelletier; Virginie Vico; Veronique Anthouard; Lee Rowen; Anup Madan;
展开▼
作者单位

Genoscope-Centre National de Sequencage, 91000, Evry, France;

展开▼
收录信息美国《科学引文索引》(SCI);美国《工程索引》(EI);美国《生物学医学文摘》(MEDLINE);美国《化学文摘》(CA);
原文格式 PDF
正文语种 eng
中图分类自然科学总论;
关键词

相似文献

外文文献
中文文献
专利

1. Comparative sequence analysis of a region on human chromosome 13q14, frequently deleted in B-cell chronic lymphocytic leukemia, and its homologous region on mouse chromosome 14. [J] . Kapanadze B, Makeeva N, Corcoran M, Genomics . 2000,第3期

机译：在B细胞慢性淋巴细胞性白血病中经常缺失的人类染色体13q14上的区域及其与小鼠染色体14上的同源区域的比较序列分析。
2. DNA sequence analysis of interlocus recombination between the human T-cell receptor gamma variable (GV) and beta diversity-joining (BD/BJ) sequences on chromosome 7 (inversion 7). [J] . Ballinger SW, Judice SA, Nicklas JA, Environmental and molecular mutagenesis. . 2002,第2期

机译：DNA序列分析人类T细胞受体伽玛变量（GV）和7号染色体上的β-多样性连接（BD / BJ）序列之间的重组（倒置7）。
3. Human artificial chromosomes generated by modification of a yeast artificial chromosome containing both human alpha satellite and single-copy DNA sequences [J] . KARLA A. HENNING, ELIZABETH A. NOVOTNY, SHEILA T. COMPTON Proceedings of the National Academy of Sciences of the United States of America . 1999,第2期

机译：通过修饰包含人α卫星和单拷贝DNA序列的酵母人工染色体产生的人类人工染色体
4. CDNA, genomic sequence cloning and sequence analysis of ribosomal protein L14 gene(rpL14) from Ailuropoda melanoleuca [C] . Xiang-Hui Li, Hou Yi-Ling, Xiang Ding, International Conference on Computer Science and Information Processing;CSIP 2012 . 2012

机译：黑线虫的核糖体蛋白L14基因（rpL14）的CDNA，基因组序列克隆和序列分析
5. Development of a mouse model for the t(10:11)(p13q14) chromosomal translocation associated with acute leukemia in humans. [D] . Caudell, David L. 2008

机译：与人类急性白血病相关的t（10:11）（p13q14）染色体易位的小鼠模型的开发。
6. Functional annotation of mammalian genomic DNA sequence by chemical mutagenesis: A fine-structure genetic mutation map of a 1- to 2-cM segment of mouse chromosome 7 corresponding to human chromosome 11p14-p15 [O] . Eugene M. Rinchik, Donald A. Carpenter, Dabney K. Johnson 2002

机译：通过化学诱变对哺乳动物基因组DNA序列进行功能注释：小鼠染色体7的1至2-cM片段对应于人类11p14-p15染色体的精细结构遗传突变图
7. Antisense inhibition of Bcr-Abl/c-Abl synthesis promotes telomerase activity and upregulates tankyrase in human leukemia cells11The GenBank accession numbers for human Bcr-Abl and human c-Abl cDNA sequences described in this paper are X02596/M24603 and X16416, respectively. ODN1/PS-ODN1 antisense sequences and ODN3/PS-ODN3 control sense sequences correspond to the nucleotide sites localized in the breakpoint cluster region (b3a2 junction) in the 9:22 chromosomal translocation (Philadelphia chromosome, accession numbers X02596 and M24603, version X02596.1, between ex. 3061 and 3121). ODN2/PS-ODN2 antisense sequences and ODN4/PS-ODN4 control sense sequences correspond to the nucleotide site of Abl proto-oncogene, localized between ex. 961 and 1021 (accession number X16416, version X16416.1). ODN5 and PS-ODN5 are nonsense sequences and did not show homology with both cDNAs. [O] . Bakalova Rumiana, Ohba Hideki, Zhelev Zhivko, 2004

机译：对Bcr-Abl / c-Abl合成的反义抑制可促进人白血病细胞中的端粒酶活性并上调tankase酶11本文描述的人Bcr-Abl和人c-Abl cDNA序列的GenBank登录号分别为X02596 / M24603和X16416。 ODN1 / PS-ODN1反义序列和ODN3 / PS-ODN3控制有义序列对应于9:22染色体易位（费城染色体，登录号X02596和M24603，版本X02596）中位于断点簇区域（b3a2连接）的核苷酸位点.1（例如3061和3121之间）。 ODN2 / PS-ODN2反义序列和ODN4 / PS-ODN4控制有义序列对应于Abl原癌基因的核苷酸位点，位于ex。 961和1021（登录号X16416，版本X16416.1）。 ODN5和PS-ODN5是无义序列，与两个cDNA没有同源性。

The DNA sequence and analysis of human chromosome 14

摘要

著录项

相似文献

相关主题

期刊订阅