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首页> 外文期刊>Nature >A discrete neuronal circuit induces a hibernation-like state in rodents
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A discrete neuronal circuit induces a hibernation-like state in rodents

机译：离散的神经元电路在啮齿动物中引起冬眠状态

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摘要

Abstract Hibernating mammals actively lower their body temperature to reduce energy expenditure when facing food scarcity1. This ability to induce a hypometabolic state has evoked great interest owing to its potential medical benefits2,3. Here we show that a hypothalamic neuronal circuit in rodents induces a long-lasting hypothermic and hypometabolic state similar to hibernation. In this state, although body temperature and levels of oxygen consumption are kept very low, the ability to regulate metabolism still remains functional, as in hibernation4. There was no obvious damage to tissues and organs or abnormalities in behaviour after recovery from this state. Our findings could enable the development of a method to induce a hibernation-like state, which would have potential applications in non-hibernating mammalian species including humans.
机译：抽象冬眠哺乳动物积极降低其体温，以减少食物稀释剂时的能量消耗1。由于其潜在的医疗福利2,3，这种诱导抑郁症州的能力引起了极大的兴趣。在这里，我们表明啮齿动物中的下丘脑神经元电路诱导类似于冬眠的长期低温和低温状态。在这种状态下，尽管氧气消耗的体温和水平保持非常低，但调节代谢的能力仍然是冬眠4中的功能。从这种状态恢复后，对组织和器官或机构的异常没有明显的损害。我们的发现可以使得开发一种诱导类似冬眠状态的方法，这将在包括人类在内的非冬眠哺乳动物物种中具有潜在的应用。

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  • 来源
    《Nature》 |2020年第7814期|109-114|共6页
  • 作者

    Tohru M. Takahashi; Genshiro A. Sunagawa; Shingo Soya; Manabu Abe; Katsuyasu Sakurai; Kiyomi Ishikawa; Masashi Yanagisawa; Hiroshi Hama; Emi Hasegawa; Atsushi Miyawaki; Kenji Sakimura; Masayo Takahashi; Takeshi Sakurai;

  • 作者单位

    International Institute for Integrative Sleep Medicine (WPI-IIIS) University of Tsukuba Tsukuba Japan;

    Laboratory for Retinal Regeneration RIKEN Center for Biosystems Dynamics Research Kobe Japan;

    International Institute for Integrative Sleep Medicine (WPI-IIIS) University of Tsukuba Tsukuba Japan;

    Department of Cellular Neurobiology Brain Research Institute Niigata University Niigata Japan|Department of Animal Model Development Brain Research Institute Niigata University Niigata Japan;

    International Institute for Integrative Sleep Medicine (WPI-IIIS) University of Tsukuba Tsukuba Japan;

    Laboratory for Retinal Regeneration RIKEN Center for Biosystems Dynamics Research Kobe Japan;

    International Institute for Integrative Sleep Medicine (WPI-IIIS) University of Tsukuba Tsukuba Japan;

    Laboratory for Cell Function Dynamics RIKEN Center for Brain Science Wako Japan;

    International Institute for Integrative Sleep Medicine (WPI-IIIS) University of Tsukuba Tsukuba Japan;

    Laboratory for Cell Function Dynamics RIKEN Center for Brain Science Wako Japan;

    Department of Animal Model Development Brain Research Institute Niigata University Niigata Japan;

    Laboratory for Retinal Regeneration RIKEN Center for Biosystems Dynamics Research Kobe Japan;

    Faculty of Medicine University of Tsukuba Tsukuba Japan|International Institute for Integrative Sleep Medicine (WPI-IIIS) University of Tsukuba Tsukuba Japan|Life Science Center Tsukuba Advanced Research Alliance (TARA) University of Tsukuba Tsukuba Japan;

  • 收录信息 美国《科学引文索引》(SCI);美国《工程索引》(EI);美国《生物学医学文摘》(MEDLINE);美国《化学文摘》(CA);
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