Closing the joint

John M. Coffin; Naomi Rosenberg

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Closing the joint

机译：闭合关节

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We are starting to understand much about how retroviruses integrate their DNA into host genomes. We know, for example, how the viral integrase carries out initial events in the process. But retrovirologists have tended to ignore the subsequent reactions, preferring to pass the buck onto 'cellular repair systems'. A report by Daniel et al. in Science may now shed the first ray of light on these systems. They have found that a cellular damage-sensing system is implicated in completing retro-viral integration.

机译：我们开始对逆转录病毒如何将其DNA整合到宿主基因组中了解得更多。例如，我们知道病毒整合酶如何在过程中进行初始事件。但是逆转录病毒学家倾向于忽略随后的反应，宁愿将责任推给“细胞修复系统”。 Daniel等人的报告。现在，《科学》杂志的这些文章可能会引起人们的关注。他们发现，细胞损伤传感系统与完成逆转录病毒整合有关。

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来源
《Nature》 |1999年第6735期|p.413415-416|共3页
作者
John M. Coffin; Naomi Rosenberg;
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收录信息美国《科学引文索引》(SCI);美国《工程索引》(EI);美国《生物学医学文摘》(MEDLINE);美国《化学文摘》(CA);
原文格式 PDF
正文语种 eng
中图分类自然科学总论;
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Closing the joint

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