首页> 外文期刊>Nature >ROLE OF INTERCELLULAR INTERACTIONS IN HETEROSYNAPTIC LONG-TERM DEPRESSION
【24h】

ROLE OF INTERCELLULAR INTERACTIONS IN HETEROSYNAPTIC LONG-TERM DEPRESSION

机译:细胞间相互作用在异位突触长期抑制中的作用

获取原文
获取原文并翻译 | 示例
           

摘要

BIDIRECTIONAL control of synaptic strength is thought to be important for the development of neuronal circuits and information storage. The demonstration of homosynaptic long-term depression(1) greatly enhances the usefulness of the synapse as a mnemonic device, but theoreticians have also seen the need for heterosynaptic decreases in synaptic efficacy, both in neuronal development(2-4) and information storage(5). Indeed, induction of long-term potentiation in one population of synapses can be associated with a modest depression at neighbouring inactive synapses in the same population of cells(6-10). Here we report that in the CA1 region of the hippocampus this heterosynaptic long-term depression has the property that its sites of induction and expression occur in different populations of cells and thus requires the spread of a signal between neurons. Such a mechanism ensures a widespread distribution of this form of plasticity. [References: 27]
机译:双向控制突触强度被认为对于神经回路和信息存储的发展很重要。同源突触长期抑制的证明(1)极大地增强了突触作为助记器的有效性,但理论家还发现,在神经元发育(2-4)和信息存储(无论是神经突触还是神经突触)中,都需要降低突触功效。 5)。确实,在一组突触中诱导长期增强作用可能与在同一细胞群中相邻的非活动突触的适度抑制有关(6-10)。在这里,我们报告说,在海马的CA1区,这种异突触的长期抑制具有以下特性:其诱导和表达位点出现在不同的细胞群中,因此需要信号在神经元之间传播。这种机制确保了这种可塑性的广泛分布。 [参考:27]

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱:kefu@zhangqiaokeyan.com

京公网安备:11010802029741号 ICP备案号:京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有
  • 客服微信

  • 服务号