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首页> 外文期刊>Pediatric Cardiology >Evidence for Early Vessel Involvement in the Dysfunctional Myocardium of Takayasu's Arteritis
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Evidence for Early Vessel Involvement in the Dysfunctional Myocardium of Takayasu's Arteritis

机译：高津市大动脉炎功能障碍心肌早期介入血管的证据

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摘要

A 15-year-old girl presented with persistent fevers, night sweats, leukocytosis, an elevated erythrocyte sedimentation rate, and a 13-pound weight loss over 2 months. Duplex Doppler scans, computed tomographic scan, and magnetic resonance imaging studies were suggestive of Takayasu's arteritis. Left ventricular dysfunction occurred during the episode of active disease, and an endomyocardial biopsy demonstrated increased HLA-DR (human leukocyte antigen-DR) on the endothelium and evidence of immune complex deposition in the walls of small vessels. One year later, after treatment with corticosteroids and resolution of clinical symptoms, repeat endomyocardial biopsy revealed focal interstitial fibrosis and persistent immune complex deposition. These results indicate that the inflammatory, vasculitic process affecting the large vessels in Takayasu's arteritis may also involve the endomyocardium and its small vessels resulting in ventricular dysfunction.
机译：一名15岁女孩在2个月内出现持续发烧，盗汗，白细胞增多，红细胞沉降率升高和体重减轻13磅的情况。双面多普勒扫描，计算机断层扫描和磁共振成像研究提示高津市的动脉炎。在活动性疾病发作期间发生左心室功能障碍，心内膜活检显示内皮细胞HLA-DR（人类白细胞抗原-DR）增加，并且免疫复合物沉积在小血管壁上。一年后，在接受皮质类固醇治疗并缓解了临床症状后，再次进行了心内膜活检，发现局灶性间质纤维化和持续的免疫复合物沉积。这些结果表明，影响高隆动脉炎中大血管的炎性血管过程也可能涉及心内膜及其小血管，导致心室功能障碍。

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  • 来源
    《Pediatric Cardiology》 |2001年第1期|74-76|共3页
  • 作者

    J.P. Breinholt; III; M. Tristani-Firouzi; J.F. Bohnsack; R.E. Shaddy;

  • 作者单位

    Department of Pediatrics Primary Children's Medical Center and the University of Utah 100 N. Medical Drive Suite 1500 Salt Lake City UT 84113 USA;

    Department of Pediatrics Primary Children's Medical Center and the University of Utah 100 N. Medical Drive Suite 1500 Salt Lake City UT 84113 USA;

    Department of Pediatrics Primary Children's Medical Center and the University of Utah 100 N. Medical Drive Suite 1500 Salt Lake City UT 84113 USA;

    Department of Pediatrics Primary Children's Medical Center and the University of Utah 100 N. Medical Drive Suite 1500 Salt Lake City UT 84113 USA;

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  • 正文语种 eng
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  • 关键词

    Key words: Takayasu's — Arteritis — Immunofluorescence;

    机译：关键词：Takayasu's-动脉炎-免疫荧光;

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