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首页> 外文期刊>Photodiagnosis and Photodynamic Therapy >Porphyrins in urine after administration of 5-aminolevulinic acid as a potential tumor marker
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Porphyrins in urine after administration of 5-aminolevulinic acid as a potential tumor marker

机译：服用5-氨基乙酰丙酸作为潜在的肿瘤标志物后尿中的卟啉

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Background: Tumor markers are commonly used for cancer screening and as indicators of therapeutic effects. Certain types of tumor have been known to produce a variety of porphyrins after 5-aminolevulinic acid (ALA) administration. In this study, porphyrins in tumor-bearing mouse urine were analyzed after oral administration of ALA in order to identify new tumor markers excreted in the urine.Methods: Porphyrin concentrations in the urine of tumor-bearing mice were measured after administration of 1.0mg of ALA (approximately 50mgkg~(-1)).Results: Porphyrin concentrations in the urine of tumor-bearing mice increased after administration of ALA. HPLC analysis of the urine revealed the existence of uroporphyrin (UP) and coproporphyrin (CP) in the urine of ALA-treated tumor-bearing mice. Furthermore, at 3 h after ALA administration, UP concentrations in the urine of tumor-bearing mice significantly increased compared to those in the urine of normal mice.Conclusion: These results suggest that UP as a precursor of heme detected in the urine of tumor-bearing mice after ALA administration is a potential marker of tumor development.
机译：背景：肿瘤标志物通常用于癌症筛查和作为治疗效果的指标。已知某些类型的肿瘤在施用5-氨基乙酰丙酸（ALA）后会产生多种卟啉。本研究通过口服ALA后对荷瘤小鼠尿中的卟啉进行分析，以鉴定尿中排泄的新肿瘤标志物。方法：给予1.0mg维生素A后，测定荷瘤小鼠尿中的卟啉浓度。结果：荷瘤小鼠尿液中的卟啉浓度升高，约为50mgkg〜（-1）。尿液的HPLC分析显示，经ALA治疗的荷瘤小鼠尿液中存在尿卟啉（UP）和共卟啉（CP）。此外，在ALA给药后3小时，荷瘤小鼠尿液中的UP浓度比正常小鼠尿液中的高。结论：这些结果表明，UP作为荷瘤血红素的前体，在正常小鼠中被检出。服用ALA后携带小鼠是肿瘤发展的潜在标志。

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