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首页> 外文期刊>Photodiagnosis and Photodynamic Therapy >Cytotoxicity of ultraviolet-C radiation on a heterogeneous population of human glioblastoma multiforme cells: Meta-analysis
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Cytotoxicity of ultraviolet-C radiation on a heterogeneous population of human glioblastoma multiforme cells: Meta-analysis

机译：紫外线-C辐射对人胶质母细胞瘤多形细胞异质群体的细胞毒性：荟萃分析

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Introduction: Current treatment strategies for glioblastoma multiforme are limited due to early recurrence and heterogeneity of the cell population that causes a varied response to treatment. Ultraviolet-C (UVC) radiation may be a potential adjuvant treatment that could theoretically be delivered locally by implantable micro-electromechanical systems that sense and kill early recurrence and/or minimally residual cancer. in vitro irradiation experiments are limited because they commonly use a single cell line. Therefore other methods are required to investigate cytotoxicity across a heterogeneous population of GBM.Methods: A meta-analysis was conducted to assess the cytotoxic effects of UVC radiation on human GBM cell lines, with or without genetic modification, in monolayer to simulate a heterogeneous model. 16 publications were included using 14 different cell lines and 19 gene vectors. Effect sizes were calculated for cell survival, viability, apoptosis and proliferation. Univariate meta-regression was used to investigate the effects of radiant exposure (J/m(2)) and timing on cytotoxicity.Results: UVC resulted in a 70.9% (CI: 63.6%-78.2%) reduction in survival, 16.6% (CI: 10.8%-22.4%) increase in apoptosis, 32.0% (CI: 9.95%-54.2%) reduction in viability, and 413.8% (CI: 95.7%-731.9%) reduction in proliferation of GBM cell lines compared to controls. Radiant exposure was significantly associated with survival (R-2 = 0.486, p 0.0001) but not with apoptosis or viability.Conclusions: This study provides more data on the therapeutic translational potential of UVC to a more clinically-realistic context. Overall, UVC is cytotoxic to GBM cell lines in aggregate and may be clinically useful when combined with genetic modification or other adjuvant treatments.
机译：简介：目前由于多形性胶质母细胞瘤的治疗策略受到局限，原因是细胞群的早期复发和异质性导致了对治疗的不同反应。紫外线-C（UVC）辐射可能是一种潜在的辅助治疗方法，理论上可以通过可植入的微机电系统在局部递送，该系统可感应并杀死早期复发和/或残留癌症最少。体外照射实验受到限制，因为它们通常使用单个细胞系。因此，还需要其他方法来研究跨异质性GBM的细胞毒性。方法：进行荟萃分析，以评估UVC辐射对具有或未经遗传修饰的人GBM细胞系的单层细胞毒性作用，以模拟异质性模型。使用14种不同的细胞系和19种基因载体，包括16种出版物。计算细胞存活，生存力，凋亡和增殖的效应大小。使用单变量荟萃回归研究辐射暴露（J / m（2））和时间对细胞毒性的影响。结果：UVC导致存活率降低70.9％（CI：63.6％-78.2％），降低16.6％（与对照组相比，CI：GBM细胞系的凋亡增加了10.8％-22.4％），生存力降低了32.0％（CI：9.95％-54.2％）和413.8％（CI：95.7％-731.9％）。辐射暴露与存活率显着相关（R-2 = 0.486，p <0.0001），但与细胞凋亡或生存力无关。结论：本研究提供了更多有关UVC在临床上更现实的治疗潜力的数据。总体而言，UVC总体上对GBM细胞系具有细胞毒作用，当与基因修饰或其他辅助治疗结合使用时，在临床上可能有用。

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