• 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Photodiagnosis and Photodynamic Therapy >Does pre-irradiation time influence the efficacy of antimicrobial photodynamic therapy?
【24h】

Does pre-irradiation time influence the efficacy of antimicrobial photodynamic therapy?

机译：预照射时间是否会影响抗微生物光动力治疗的疗效？

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Antimicrobial photodynamic therapy (aPDT) has emerged as a promising antimicrobial treatment to control microorganisms including those involved in oral diseases, especially dental caries. Hence, the aim of this study was to evaluate the influence of aPDT - pre-irradiation time (PIT), at different periods, on antimicrobial rate of Streptococcus mutans (S. mutans). A standard suspension of S. mutans UA159 was prepared and submitted at sensitization of 0.005 % methylene blue (MB) for 0, 1, 3 and 5 min (G1 - G4 groups, respectively) and irradiated with a red laser (660 nm; 321 J/cm(2); 9 J; 90 s) afterward. A control group using PBS instead of MB was performed as well (G5). The number of colony-forming units (CFU)/mL was recorded, transformed into log(10) and analyzed by ANOVA and Tukey's test at a cutoff value at 0.05. Overall, the aPDT groups tested achieved a bacterial reduction 1-log(10) when compared to G5 (p 0.05) with no statistical difference among the different PIT tested. The need of PIT before aPDT application deserves attention, since its time reduction implies on shorter clinical approaches without compromising the photodynamic antibacterial efficacy in the in vitro parameters employed.
机译：抗微生物光动力治疗（APDT）被出现为有前途的抗菌治疗，以控制包括参与口腔疾病，特别是龋齿的微生物。因此，本研究的目的是评估APDT - 预照射时间（PIT）在不同时期对链球菌的抗微生物率（S. mutans）的影响。制备S.UA159的标准悬浮液，并在0.005％亚甲基蓝（MB）的致敏0,1,3和5分钟（G1 - G4基团）中提交并用红色激光照射（660nm; 321 J / CM（2）; 9 J; 90 S）之后。还执行使用PBS而不是MB的对照组（G5）。记录菌落形成单元（CFU）/ mL的数量，转化为对数（10），并通过ANOVA和Tukey的测试分析0.05的截止值。总的来说，与G5（P <0.05）相比，测试的APDT组在与G5（P <0.05）相比时达到了细菌还原> 1-对数（10），不同的坑之间没有统计学差异。在APDT申请之前的需求值得注意，因为它的时间减少意味着在不影响所用体外参数中的光动力学抗菌效果的情况下缩短了较短的临床方法。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号