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首页> 外文期刊>Proceedings of the National Academy of Sciences of the United States of America >Mutations of -aminobutyric acid and glycine receptors change alcohol cutoff: Evidence for an alcohol receptor?
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Mutations of -aminobutyric acid and glycine receptors change alcohol cutoff: Evidence for an alcohol receptor?

机译：-氨基丁酸和甘氨酸受体的突变改变了酒精的截止值：是否有酒精受体的证据？

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摘要

Alcohols in the homologous series of n- alcohols increase in central nervous system depressant po- tency with increasing chain length until a "cutoff" is reached, after which further increases in molecular size no longer increase alcohol potency. A similar phenomenon has been observed in the regulation of ligand-gated ion channels by alcohols. Different ligand-gated ion channels exhibit radically different cutoff points, suggesting the existence of discrete alcohol binding pockets of variable size on these membrane proteins. The identification of amino acid residues that de- termine the alcohol cutoff may, therefore, provide information about the location of alcohol binding sites.
机译：正链醇的同源系列中的醇会随着链长的增加而增加中枢神经系统的抑制力，直至达到“截断值”为止，此后分子大小的进一步增加不再增加醇的效价。在醇对配体门控离子通道的调节中也观察到类似现象。不同的配体门控离子通道表现出截然不同的截止点，表明这些膜蛋白上存在离散的可变大小的醇结合口袋。因此，确定醇截止值的氨基酸残基的鉴定可以提供有关醇结合位点位置的信息。

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