A widely expressed βIII spectrin associated with Golgi and cytoplasmic vesicles

Michael C. Stankewich; William T. Tse; Luanne L. Peters

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A widely expressed βIII spectrin associated with Golgi and cytoplasmic vesicles

机译：广泛表达的与高尔基体和胞浆囊泡相关的βIII血影蛋白

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Spectrin is an important structural compo- nent of the plasma membrane skeleton. Heretofore- unidentified isoforms of spectrin also associate with Golgi and other organelles. We have discovered another member of the β-spectrin gene family by homology searches of the GenBank databases and by 5' rapid amplification of cDNA ends of human brain cDNAs. Collectively, 7,938 nucleotides of con- tiguous clones are predicted to encode a 271,294-Da protein, called βIII spectrin, with conserved actin-, protein 4.1-, and ankyrin-binding domains, membrane association domains 1 and 2, a spectrin dimer self-association site, and a pleckstrin- homology domain.

机译：血影蛋白是质膜骨架的重要结构成分。迄今未确认的血影蛋白同工型也与高尔基体和其他细胞器有关。我们已经通过GenBank数据库的同源搜索以及人脑cDNA cDNA末端的5'快速扩增发现了β-spectrin基因家族的另一个成员。总的来说，连续克隆的7938个核苷酸预计会编码271,294-Da蛋白，称为βIII血影蛋白，具有保守的肌动蛋白，蛋白4.1和锚蛋白结合结构域，膜缔合结构域1和2，血影蛋白二聚体自身结构。关联位点和一个pleckstrin同源域。

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《Proceedings of the National Academy of Sciences of the United States of America》 |1998年第24期|p.14158-14163|共6页
作者
Michael C. Stankewich; William T. Tse; Luanne L. Peters;
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收录信息美国《科学引文索引》(SCI);美国《生物学医学文摘》(MEDLINE);美国《化学文摘》(CA);
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正文语种 eng
中图分类自然科学总论;
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1. Identification of a small cytoplasmic ankyrin (AnkG119) in the kidney and muscle that binds beta I sigma spectrin and associates with the Golgi apparatus. [J] . P Devarajan, P R Stabach, A S Mann, Journal of cell biology . 1996,第4期

机译：鉴定肾脏和肌肉中结合βIσ血影蛋白并与高尔基体相关的小胞浆锚蛋白（AnkG119）。
2. βIII Spectrin Regulates the Structural Integrity and the Secretory Protein Transport of the Golgi Complex [J] . Laia Salcedo-Sicilia, Susana Granell, Marko Jovic, The Journal of biological chemistry . 2013,第4期

机译：βIII光谱调节Golgi复合物的结构完整性和分泌蛋白转运
3. Beta-III spectrin mutation L253P associated with spinocerebellar ataxia type 5 interferes with binding to Arp1 and protein trafficking from the Golgi. [J] . Clarkson YL, Gillespie T, Perkins EM, Human Molecular Genetics . 2010,第18期

机译：与5型脊髓小脑共济失调相关的Beta-III血影蛋白突变L253P干扰与Arp1的结合和高尔基体的蛋白运输。
4. DEVELOPMENT INTO THE FUNCTIONAL CHLOROPLAST INVOLVES A RECEPTOR-LIKE KINASE IN GOLGI VESICLES IN ARABWOPSIS [C] . Shingo Goto, Yasuo Niwa, Hirokazu Kobayashi International Congress of Photosynthesis . 2005

机译：在ArabWopsis中的高尔基囊泡中涉及一种受体样激酶
5. A new role and mechanistic model for the conserved oligomeric Golgi (COG) complex in tethering retrograde vesicles to the Golgi apparatus. [D] . Willett, Rose A. 2014

机译：保守的低聚高尔基体（COG）复合体在逆行囊泡与高尔基体的束缚中的新作用和机制模型。
6. A widely expressed βIII spectrin associated with Golgi and cytoplasmic vesicles [O] . Michael C. Stankewich, William T. Tse, Luanne L. Peters, 1998

机译：广泛表达的与高尔基体和胞浆囊泡相关的βIII血影蛋白
7. Identification of a small cytoplasmic ankyrin (AnkG119) in the kidney and muscle that binds beta I sigma spectrin and associates with the Golgi apparatus [O] . 1996

机译：鉴定肾脏和肌肉中结合βI sigma血影蛋白并与高尔基体相关的小胞浆锚蛋白（AnkG119）

A widely expressed βIII spectrin associated with Golgi and cytoplasmic vesicles

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