Tumor induction by a transformation-defective polyoma virus mutant blocked in signaling through Shc

Roderick Bronson; Clyde Dawe; John Carroll

首页> 外文期刊>Proceedings of the National Academy of Sciences of the United States of America >Tumor induction by a transformation-defective polyoma virus mutant blocked in signaling through Shc

【24h】

Tumor induction by a transformation-defective polyoma virus mutant blocked in signaling through Shc

机译：通过Shc的信号传导受阻的转化缺陷型多瘤病毒突变体诱导的肿瘤

获取原文

获取原文并翻译 | 示例

掌桥外文数据库（机构版） >>

开具论文收录证明 >>

文献代查 >>

页面导航

摘要
著录项
相似文献
相关主题

摘要

Transformation of cells in culture by poly- oma virus requires integration of signals downstream of middle T-Shc and middle T-phosphatidylinositol 3-kinase interactions, but the same is not true for induction of tumors in the mouse. Thus, a middle T mutant defective in transfor- mation and blocked in binding Shc is able to induce a broad spectrum of tumors after inoculation into newborn mice. The "tumor profile" induced by the mutant shows enhancement of tumors at some sites and reductions at others but otherwise resembles that induced by the wild-type virus.

机译：polyoma病毒在培养物中转化细胞需要整合中间T-Shc和中间T-磷脂酰肌醇3-激酶相互作用的下游信号，但对于诱导小鼠肿瘤却并非如此。因此，在转化成新生小鼠后，转化中有缺陷并被Shc结合阻断的中间T突变体能够诱导多种肿瘤。突变体诱导的“肿瘤概况”显示某些部位的肿瘤增强而其他部位的肿瘤减少，但与野生型病毒诱导的相似。

著录项

来源
《Proceedings of the National Academy of Sciences of the United States of America》 |1997年第15期|p.7954-7958|共5页
作者
Roderick Bronson; Clyde Dawe; John Carroll;
展开▼
作者单位

展开▼
收录信息美国《科学引文索引》(SCI);美国《生物学医学文摘》(MEDLINE);美国《化学文摘》(CA);
原文格式 PDF
正文语种 eng
中图分类自然科学总论;
关键词

相似文献

外文文献
中文文献
专利

1. Recovery of avian sarcoma virus from tumors induced by transformation-defective mutants. [J] . H Hanafusa, C C Halpern, D L Buchhagen, The Journal of Experomental Medicine . 1977,第6期

机译：从转化缺陷型突变体诱导的肿瘤中恢复禽肉瘤病毒。
2. Nucleotide Sequence Relationships of Avian RNA Tumor Viruses: Measurement of the Deletion in a Transformation-Defective Mutant of Rous Sarcoma Virus [J] . P. E. Neiman, S. E. Wright, C. McMillin, Journal of Virology . 1974,第4期

机译：禽RNA肿瘤病毒的核苷酸序列关系：Rous Sarcoma病毒转化缺陷突变体中缺失的测量
3. Nucleotide Sequence Relationships of Avian RNA Tumor Viruses: Measurement of the Deletion in a Transformation-Defective Mutant of Rous Sarcoma Virus [J] . P. E. Neiman, S. E. Wright, C. McMillin, Journal of Virology . 1974,第4期

机译：禽RNA肿瘤病毒的核苷酸序列关系：Rous Sarcoma病毒转化缺陷突变体中缺失的测量
4. Efficient intracellular delivery of proteins and low molecular weight substances via polyoma virus-like particles (PVLP) [C] . Christoph M.B.Stark, Andrea Abbing, Ulrich K.Blaschke, European Peptide Symposium . 2002

机译：通过多瘤病毒样颗粒（PVLP）高效细胞内递送蛋白质和低分子量物质
5. Suppressor of cytokine signaling 3 blocks breast tumor kinase activation of STAT3 transcription factor. [D] . Gao, Yiwei. 2010

机译：细胞因子信号传导抑制因子3抑制STAT3转录因子激活乳腺肿瘤激酶。
6. Tumor induction by a transformation-defective polyoma virus mutant blocked in signaling through Shc [O] . Roderick Bronson, Clyde Dawe, John Carroll, 1997

机译：转化缺陷型多瘤病毒突变体通过Shc的信号传导阻断了肿瘤的诱导
7. Tumor Induction by SE Polyoma Virus and the Inhibition of Tumors by Specific Neutralizing Antibodies [O] . Stewart, Sarah E., Eddy, Bernice E. 1959

机译：SE多瘤病毒对肿瘤的诱导和特异性中和抗体对肿瘤的抑制作用
8. Report on Carcinogens (RoC) Concept: Selected Viruses. Epstein--Barr Virus, Human ImmunodeficiencynVirus Type 1, Human T--Cell Lymphotropic Virus Type 1, Kaposi Sarcoma--Associated Herpes Virus, and nMerkel Cell Polyoma Virus. [R] . 2016

机译：关于致癌物（RoC）概念的报告：选定的病毒。爱泼斯坦 - 巴尔病毒，人类免疫缺陷病毒1型，人类T细胞淋巴细胞病毒1型，卡波西肉瘤 - 相关疱疹病毒和nmerkel细胞多瘤病毒。

Tumor induction by a transformation-defective polyoma virus mutant blocked in signaling through Shc

摘要

著录项

相似文献

相关主题

期刊订阅