Screening for imprinted genes by allelic message display: Identification of a paternally expressed gene Impact on mouse chromosome 18

Yuriko Hagiwara; Momoki Hirai; Kazutoshi Nishiyama

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Screening for imprinted genes by allelic message display: Identification of a paternally expressed gene Impact on mouse chromosome 18

机译：通过等位基因信息显示筛选印迹基因：鉴定父本表达的基因对小鼠染色体18的影响

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A systematic screen termed the allelic mes- sage display (AMD) was developed for the hunting of im- printed genes. In AMD, differential display PCR is adopted to image allelic expression status of multiple polymorphic tran- scripts in two parental mouse strains, reciprocal F1 hybrids and pooled backcross progenies. From the displayed patterns, paternally and maternally expressed transcripts can be un- equivocally identified. The effectiveness of AMD screening was clearly demonstrated by the identification of a paternally expressed gene Impact on mouse chromosome 18, the pre- dicted product of which belongs to the YCR59c/yigZ hypo- thetical protein family composed of yeast and bacterial pro- teins with currently unknown function.

机译：开发了一种称为等位基因信息展示（AMD）的系统屏幕，用于寻找印迹基因。在AMD中，采用差异显示PCR来成像两个亲本小鼠品系，倒数F1杂种和回交后代的多个多态转录物的等位基因表达状态。从显示的模式中，可以明确地确定父本和母本表达的转录本。通过鉴定父本表达的基因Impact on mouse染色体18可以清楚地证明AMD筛选的有效性，该基因的预测产物属于YCR59c / yigZ假想蛋白家族，由酵母和细菌蛋白组成，目前功能未知。

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《Proceedings of the National Academy of Sciences of the United States of America》 |1997年第17期|p.9249-9254|共6页
作者
Yuriko Hagiwara; Momoki Hirai; Kazutoshi Nishiyama;
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收录信息美国《科学引文索引》(SCI);美国《生物学医学文摘》(MEDLINE);美国《化学文摘》(CA);
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正文语种 eng
中图分类自然科学总论;
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1. Identification of the mouse paternally expressed imprinted gene Zdbf2 on chromosome 1 and its imprinted human homolog ZDBF2 on chromosome 2. [J] . Kobayashi H, Yamada K, Morita S Genomics . 2009,第5期

机译：小鼠父本在染色体1上表达的印迹基因Zdbf2及其在染色体2上的印迹人类同源物ZDBF2的鉴定。
2. Real-time PCR analysis of candidate imprinted genes on mouse chromosome 11 shows balanced expression from the maternal and paternal chromosomes and strain-specific variation in expression levels. [J] . Tuskan RG, Tsang S, Sun Z, Epigenetics: official journal of the DNA Methylation Society . 2008,第1期

机译：小鼠11号染色体上候选印迹基因的实时PCR分析显示，母本和父本染色体表达均衡，并且菌株特异性表达水平有所差异。
3. Activation of paternally expressed imprinted genes in newly derived germline-competent mouse parthenogenetic embryonic stem cell lines. [J] . Jiang H, Sun B, Wang W, Cell research. . 2007,第9期

机译：在新衍生的具有生殖能力的小鼠孤雌生殖胚胎干细胞系中父系表达的印迹基因的激活。
4. Identification of differentially expressed genes in atopic dermatms-prone NC/Nga mouse [C] . ITADAKI YAMAGUCHI, SELJI KAWAMOTO, TSUNEHIRO AKI, Annual Meeting of the Japanese Association for Animal Cell Technology . 2002

机译：特应性皮肤 - 易受NC / NGA小鼠差异表达基因的鉴定
5. Human immunoglobulin lambda light chain genes and lambda-like genes: Identification and characterization of a new C lambda gene and chromosomal localization and expression of human lambda-like genes in pre-B lymphocytes. [D] . Bauer, Thomas Roy, Jr. 1992

机译：人免疫球蛋白λ轻链基因和λ样基因：新的Cλ基因的鉴定和表征以及前λB淋巴细胞中人λ样基因的染色体定位和表达。
6. Screening for imprinted genes by allelic message display: Identification of a paternally expressed gene Impact on mouse chromosome 18 [O] . Yuriko Hagiwara, Momoki Hirai, Kazutoshi Nishiyama, 1997

机译：通过等位基因信息显示筛选印迹基因：鉴定父本表达的基因对小鼠染色体18的影响
7. Identification of the mouse paternally expressed imprinted gene Zdbf2 on chromosome 1 and its imprinted human homolog ZDBF2 on chromosome 2 [O] . Kobayashi Hisato, Yamada Kaori, Morita Shinnosuke, 2009

机译：小鼠父本在染色体1上表达的印迹基因Zdbf2及其在染色体2上的印迹人类同源物ZDBF2的鉴定

Screening for imprinted genes by allelic message display: Identification of a paternally expressed gene Impact on mouse chromosome 18

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