Backtracking leukemia to birth: Identification of clonotypic gene fusion sequences in neonatal blood spots

Karin B. Gale; Anthony M. Ford; Reinald Repp

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Backtracking leukemia to birth: Identification of clonotypic gene fusion sequences in neonatal blood spots

机译：回溯白血病至出生：新生儿血斑中克隆型基因融合序列的鉴定

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Epidemiological evidence has suggested that some pediatric leukemias may be initiated in utero and, for some pairs of identical twins with concordant leukemia, this possibility has been strongly endorsed by molecular studies of clonality. Direct evidence for a prenatal origin can only be derived by prospective or retrospective detection of leukemia-specific mo- lecular abnormalities in fetal or newborn samples. We report a PCR-based method that has been developed to scrutinize neo- natal blood spots (Guthrie cards) for the presence of numerically infrequent leukemic cells at birth in individuals who subse- quently developed leukemia.

机译：流行病学证据表明，某些小儿白血病可能是在子宫内引发的，并且对于一些成对的同卵双胞胎患有一致的白血病，这种可能性已被克隆性的分子研究强烈认可。只能通过前瞻性或回顾性检测胎儿或新生儿样本中的白血病特异性分子异常来获得产前起源的直接证据。我们报道了一种基于PCR的方法，该方法已被开发用于检查新生儿血斑（Guthrie卡）中出生后继发白血病的个体中数字上很少的白血病细胞的存在。

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《Proceedings of the National Academy of Sciences of the United States of America》 |1997年第25期|p.13850-13954|共105页
作者
Karin B. Gale; Anthony M. Ford; Reinald Repp;
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收录信息美国《科学引文索引》(SCI);美国《生物学医学文摘》(MEDLINE);美国《化学文摘》(CA);
原文格式 PDF
正文语种 eng
中图分类自然科学总论;
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1. Somatic Structural Alterations in Childhood Leukemia Can Be Backtracked in Neonatal Dried Blood Spots by Use of Whole-Genome Sequencing and Digital PCR [J] . Taylan Fulya, Bang Benedicte, Ofverholm Ingegerd Ivanov, Clinical Chemistry: Journal of the American Association for Clinical Chemists . 2019,第2期

机译：儿童白血病中的体细胞结构改变可以通过使用全基因组测序和数字PCR在新生儿干血斑中重新分发
2. The ETV6/RUNX1 fusion transcript is not detected in RNA isolated from neonatal dried blood spots from children later diagnosed with the corresponding leukemia [J] . BarbanyG., GauffinF., ?fverholmI., Leukemia and lymphoma . 2013,第12期

机译：在从后来被诊断出患有相应白血病的儿童的新生儿干血斑中分离的RNA中未检测到ETV6 / RUNX1融合转录本
3. Origins of STIL‐TAL1 STIL‐TAL1 fusion genes in children who later developed paediatric T‐cell acute lymphoblastic leukaemia: An investigation of neonatal blood spots [J] . Gustafsson Britt M., Mattsson Kristin, Bogdanovic Gordana, Pediatric blood & cancer . 2018,第11期

机译：STIL-TAL1 STIL-TAL1融合基因的起源于后来发育儿科T细胞急性淋巴细胞白血病的儿童：新生儿血斑的调查
4. Untargeted Metabolomics of Archived Dried Blood Spots Reveals Lipid Modulation at Birth Associated with Pediatric Acute Lymphoblastic Leukemia [C] . Lauren Petrick, Courtney Schiffman, William M. Edmonds, Joint annual meeting of the International Society of Exposure Science and the International Society for Environmental Epidemiology . 2018

机译：未定目标的代谢组学的干血斑代谢组揭示了与小儿急性淋巴细胞白血病相关的出生时的脂质调节。
5. Identification and characterization of a novel NUP98-PHF23 fusion gene from acute myeloid leukemia. [D] . Reader, Jocelyn Christine. 2009

机译：急性髓细胞白血病的新型NUP98-PHF23融合基因的鉴定和表征。
6. Backtracking leukemia to birth: Identification of clonotypic gene fusion sequences in neonatal blood spots [O] . Karin B. Gale, Anthony M. Ford, Reinald Repp, 1997

机译：白血病回溯至出生：新生儿血斑中克隆型基因融合序列的鉴定
7. Somatic Structural Alterations in Childhood Leukemia Can Be Backtracked in Neonatal Dried Blood Spots by Use of Whole-Genome Sequencing and Digital PCR [O] . Fulya Taylan, Benedicte Bang, Ingegerd Ivanov Öfverholm, 2019

机译：儿童白血病中的体细胞结构改变可以通过使用全基因组测序和数字PCR在新生儿干血斑中重新分发

Backtracking leukemia to birth: Identification of clonotypic gene fusion sequences in neonatal blood spots

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