Cleavage of actin by interleukin 1β-converting enzyme to reverse DNase I inhibition

Celik Kayalar; Tonis Ord; M. Pia Testa

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Cleavage of actin by interleukin 1β-converting enzyme to reverse DNase I inhibition

机译：白介素1β转化酶切割肌动蛋白以逆转DNase I抑制

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Three of the predominant features of apo- ptosis are internucleosomal DNA fragmentation, plasma membrane bleb formation, and retraction of cell processes. We demonstrate that actin is a substrate for the proapoptotic cysteine protease interleukin 1β-converting enzyme. Actin cleaved by interleukin 1β-converting enzyme can neither inhibit DNase I nor polymerize to its filamentous form as effectively as intact actin. These findings suggest a mechanism for the coordination of the proteolytic, endonucleolytic, and morphogenetic aspects of apoptosis.

机译：细胞凋亡的三个主要特征是核小体间的DNA片段化，质膜起泡形成和细胞过程的退缩。我们证明肌动蛋白是促凋亡的半胱氨酸蛋白酶白介素1β转换酶的底物。被白介素1β转化酶切割的肌动蛋白既不能抑制DNase I，也不能像完整的肌动蛋白一样有效地聚合成丝状。这些发现提示了凋亡的蛋白水解，内切核酸和形态发生方面的协调机制。

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《Proceedings of the National Academy of Sciences of the United States of America》 |1996年第5期|p.2234-2238|共5页
作者
Celik Kayalar; Tonis Ord; M. Pia Testa;
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收录信息美国《科学引文索引》(SCI);美国《生物学医学文摘》(MEDLINE);美国《化学文摘》(CA);
原文格式 PDF
正文语种 eng
中图分类自然科学总论;
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6. Cleavage of actin by interleukin 1 beta-converting enzyme to reverse DNase I inhibition. [O] . C Kayalar, T Ord, M P Testa, 1996

机译：白介素1β转化酶对肌动蛋白的切割可逆转DNase I的抑制作用。
7. Cleavage of actin by interleukin 1 beta-converting enzyme to reverse DNase I inhibition. [O] . Kayalar, C, Ord, T, Testa, M P, 1996

机译：白介素1β转化酶对肌动蛋白的切割可逆转DNase I的抑制作用。

Cleavage of actin by interleukin 1β-converting enzyme to reverse DNase I inhibition

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