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首页> 外文期刊>Proceedings of the National Academy of Sciences of the United States of America >Molecular cloning of the Golgi apparatus uridine diphosphate-N-acetylglucosamine transporter from Kluyveromyces lactis
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Molecular cloning of the Golgi apparatus uridine diphosphate-N-acetylglucosamine transporter from Kluyveromyces lactis

机译:乳酸克鲁维酵母中高尔基体尿苷二磷酸-N-乙酰氨基葡萄糖转运蛋白的分子克隆

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摘要

The mannan chains of Klyveromyces lactis mannoproteins are similar to those of Saccharomyces cerevisiae except that they lack mannose phosphate and have terminal α1 - 2-linked N-acetylglucosamine. The biosynthesis of these chains probably occurs in the lumen of the Golgi apparatus, by analogy to S. cerevisiae. The sugar donors, GDP-mannose and UDP-GlcNAc, must first be transported from the cytosol, their site of synthesis, via specific Golgi membrane transport- ers into the lumen where they are substrates in the biosyn- thesis of these mannoproteins.
机译:乳酸克鲁维酵母甘露糖蛋白的甘露聚糖链与酿酒酵母的甘露聚糖链相似,除了它们缺少甘露糖磷酸酯并且具有末端α1-2连接的N-乙酰基葡糖胺。类似于酿酒酵母,这些链的生物合成可能发生在高尔基体腔中。糖供体GDP-甘露糖和UDP-GlcNAc必须首先通过特定的高尔基膜转运蛋白从它们的合成位点胞质溶胶中转运到内腔中,这些腔体是这些甘露糖蛋白生物合成中的底物。

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