Megalin-mediated endocytosis of transcobalamin-vitamin-B_12 complexes suggests a role of the receptor in vitamin-B_12 homeostasis

Soren K. Moestrup; Henrik Birn; Per B. Fischer

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Megalin-mediated endocytosis of transcobalamin-vitamin-B_12 complexes suggests a role of the receptor in vitamin-B_12 homeostasis

机译：巨蛋白介导的钴胺素-维生素B_12复合物的内吞作用表明该受体在维生素B_12体内稳态中的作用

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Kidney cortex is a main target for circulating vitamin B_12 (cobalamin) in complex with transcobalamin (TC). Ligand blotting of rabbit kidney cortex with rabbit ~125I-TC-B12 and human TC-~57Co-B_12 revealed an exclusive binding to megalin, a 600-kDa endocytic receptor present in renal proximal tubule epithelium and other absorptive epi- thelia. The binding was Ca~2+ dependent and inhibited by receptor-associated protein (RAP).

机译：肾脏皮层是循环维生素B_12（钴胺素）与反钴胺素（TC）结合的主要靶标。用兔〜125I-TC-B12和人TC-〜57Co-B_12进行的兔肾皮质配体印迹显示，其与megalin形成排他性结合，megalin是存在于肾近端小管上皮和其他吸收性上皮中的600 kDa内吞受体。结合是Ca 2+依赖性的，并被受体相关蛋白（RAP）抑制。

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《Proceedings of the National Academy of Sciences of the United States of America》 |1996年第16期|p.8612-8617|共6页
作者
Soren K. Moestrup; Henrik Birn; Per B. Fischer;
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收录信息美国《科学引文索引》(SCI);美国《生物学医学文摘》(MEDLINE);美国《化学文摘》(CA);
原文格式 PDF
正文语种 eng
中图分类自然科学总论;
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6. Megalin-mediated endocytosis of transcobalamin-vitamin-B12 complexes suggests a role of the receptor in vitamin-B12 homeostasis. [O] . S K Moestrup, H Birn, P B Fischer, 1996

机译：巨蛋白介导的钴胺素-维生素B12复合物的内吞作用表明该受体在维生素B12体内平衡中的作用。
7. Megalin-mediated endocytosis of transcobalamin-vitamin-B12 complexes suggests a role of the receptor in vitamin-B12 homeostasis. [O] . Moestrup, S K, Birn, H, Fischer, P B, 1996

机译：巨蛋白介导的钴胺素-维生素B12复合物的内吞作用表明该受体在维生素B12体内平衡中的作用。

Megalin-mediated endocytosis of transcobalamin-vitamin-B_12 complexes suggests a role of the receptor in vitamin-B_12 homeostasis

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