Mutant conformation of p53 translated in vitro or in vivo requires functional HSP90

Mikhail V. Blagosklonny; Jeffrey Toretsky; Sean Bohen

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Mutant conformation of p53 translated in vitro or in vivo requires functional HSP90

机译：体外或体内翻译的p53突变构象需要功能性HSP90

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The p53 mutant, 143, was translated in vitro in either rabbit reticulocyte lysate (RRL) or wheat germ extract (WGE). In RRL, p53-143 protein of both mutant and wild-type conformation, as detected immunologically with conformation-specific antibodies, was translated. The chap- erone protein HSP90, present in RRL, was found to co- precipitate only with the mutated conformation of p53.

机译：p53突变体143在兔网织红细胞裂解液（RRL）或小麦胚芽提取物（WGE）中进行了体外翻译。在RRL中，翻译了用构象特异性抗体免疫检测到的突变型和野生型构象的p53-143蛋白。发现RRL中存在的伴侣蛋白HSP90仅与p53的突变构象共沉淀。

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《Proceedings of the National Academy of Sciences of the United States of America》 |1996年第16期|p.8379-8383|共5页
作者
Mikhail V. Blagosklonny; Jeffrey Toretsky; Sean Bohen;
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收录信息美国《科学引文索引》(SCI);美国《生物学医学文摘》(MEDLINE);美国《化学文摘》(CA);
原文格式 PDF
正文语种 eng
中图分类自然科学总论;
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1. Functional inactivation of endogenous MDM2 and CHIP by HSP90 causes aberrant stabilization of mutant p53 in human cancer cells. [J] . Li D, Marchenko ND, Schulz R, Molecular cancer research: MCR . 2011,第5期

机译：HSP90对内源性MDM2和CHIP的功能失活会导致人类癌细胞中突变型p53的异常稳定。
2. CPe-III-S Metabolism in Vitro and in Vivo and Molecular Simulation of Its Metabolites Using a p53-R273H Mutant [J] . Xue Zhaohui, Wen Haichao, Wang Cen, Journal of Agricultural and Food Chemistry . 2016,第38期

机译：使用p53-R273H突变体进行CPe-III-S体内和体外代谢及其代谢物的分子模拟
3. Trans-splicing repair of mutant p53 suppresses the growth of hepatocellular carcinoma cells in vitro and in vivo [J] . Xingxing He, Fang Liu, Jingjun Yan, Scientific reports. . 2015,第1期

机译：突变体p53的跨剪接修复在体外和体内抑制肝癌细胞的生长。
4. In vivo conformational dynamics of Hsp90 and its interactors [C] . Juan D. Chavez, Devin K. Schweppe, Jimmy K. Eng, ASMS Conference on Mass Spectrometry and Allied Topics . 2016

机译：HSP90及其交流剂的体内构象动态
5. Comparing mutant p53 and a wild-type p53 isoform, p47: Rationale for the selection of mutant p53 in tumours. [D] . Marini, Wanda. 2009

机译：比较突变体p53和野生型p53同种型，p47：选择肿瘤中突变体p53的原理。
6. Mutant conformation of p53 translated in vitro or in vivo requires functional HSP90. [O] . M V Blagosklonny, J Toretsky, S Bohen, 1996

机译：体外或体内翻译的p53突变构象需要功能性HSP90。
7. Mutant conformation of p53 translated in vitro or in vivo requires functional HSP90. [O] . Blagosklonny, M V, Toretsky, J, Bohen, S, 1996

机译：体外或体内翻译的p53突变构象需要功能性HSP90。
8. In Vivo DNA Binding Properties of Wild-type and Mutant p53 Proteins in Mammary Cell Lines During the Course of Cell Cycle [R] . Bargonetti, J. , Fleissner, E. 1998

机译：细胞周期过程中乳腺细胞系中野生型和突变型p53蛋白的体内DNa结合特性

Mutant conformation of p53 translated in vitro or in vivo requires functional HSP90

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