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首页> 外文期刊>Proceedings of the National Academy of Sciences of the United States of America >Transcranial magnetic stimulation modulates the brain's intrinsic activity in a frequency-dependent manner
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Transcranial magnetic stimulation modulates the brain's intrinsic activity in a frequency-dependent manner

机译：经颅磁刺激以频率依赖性方式调节大脑的内在活动

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摘要

Intrinsic activity in the brain is organized into networks. Although constrained by their anatomical connections, functional correlations between nodes of these networks reorganize dynamically. Dynamic organization implies that couplings between network nodes can be reconfigured to support processing demands. To explore such reconfigurations, we combined repetitive transcranial magnetic stimulation (rTMS) and functional connectivity MRI (fcMRI) to modulate cortical activity in one node of the default network, and assessed the effect of this upon functional correlations throughout the network. Two different frequencies of rTMS to the same default network node (the left posterior inferior parietal lobule, IplPL) induced two topographically distinct changes in functional connectivity. High-frequency rTMS to IplPL decreased functional correlations between cortical default network nodes, but not between these nodes and the hippocampal formation. In contrast, low frequency rTMS to IplPL did not alter connectivity between cortical default network nodes, but increased functional correlations between IplPL and the hippocampal formation. These results suggest that the default network is composed of (at least) two subsystems. More broadly, the finding that two rTMS stimulation regimens to the same default network node have distinct effects reveals that this node is embedded within a network that possesses multiple, functionally distinct relationships among its distributed partners.
机译：大脑中的内在活动被组织成网络。尽管受到它们的解剖学联系的约束，但是这些网络的节点之间的功能相关性是动态重组的。动态组织意味着可以重新配置网络节点之间的耦合以支持处理需求。为了探索这种重构，我们结合了重复经颅磁刺激（rTMS）和功能连接性MRI（fcMRI）来调节默认网络的一个节点中的皮质活动，并评估其对整个网络功能相关性的影响。到同一默认网络节点（左后顶上小叶，IplPL）的两个不同频率的rTMS引起功能连接性的两个拓扑上明显不同的变化。高频rTMS到IplPL降低了皮质默认网络节点之间的功能相关性，但没有降低这些节点与海马结构之间的功能相关性。相比之下，低频rTMS到IplPL不会改变皮质默认网络节点之间的连通性，但是会增加IplPL与海马结构之间的功能相关性。这些结果表明，默认网络由（至少）两个子系统组成。更广泛地说，对同一默认网络节点的两个rTMS刺激方案具有不同作用的发现表明，该节点嵌入在一个网络中，该网络在其分布式伙伴之间具有多个功能上不同的关系。

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  • 作者

    Mark C. Eldaief; Mark A. Halko; Randy L. Buckner; Alvaro Pascual-Leone;

  • 作者单位

    Berenson-Allen Center for Noninvasive Brain Stimulation,Division of Cognitive Neurology, Department of Neurology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215;

    Berenson-Allen Center for Noninvasive Brain Stimulation;

    Department of Psychology,Center for Brain Science, Harvard University, Cambridge, MA 02138,Athinoula A. Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Charlestown, MA 02129,Department of Psychiatry, Massachusetts General Hospital/Harvard Medical School, Boston, MA 02215,Howard Hughes Medical Institute, Cambridge, MA 02138;

    Berenson-Allen Center for Noninvasive Brain Stimulation,Division of Cognitive Neurology, Department of Neurology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215;

  • 收录信息 美国《科学引文索引》(SCI);美国《生物学医学文摘》(MEDLINE);美国《化学文摘》(CA);
  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类
  • 关键词

    network dynamics; resting-state functional MRI; hippocampus; medial prefrontal cortex;

    机译：网络动态;静态MRI海马内侧前额叶皮层;

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