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首页> 外文期刊>Proceedings of the National Academy of Sciences of the United States of America >A role for suppressed incisor cuspal morphogenesis in the evolution of mammalian heterodont dentition
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A role for suppressed incisor cuspal morphogenesis in the evolution of mammalian heterodont dentition

机译：抑制门牙牙形态发生在哺乳动物异牙牙列进化中的作用

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摘要

Changes in tooth shape have played a major role in vertebrate evolution with modification of dentition allowing an organism to adapt to new feeding strategies. The current view is that molar teeth evolved from simple conical teeth, similar to canines, by progressive addition of extra "cones" to form progressively complex multicuspid crowns. Mammalian incisors, however, are neither conical nor multicuspid, and their evolution is unclear. We show that hypomorphic mutation of a cell surface receptor, Lrp4, which modulates multiple signaling pathways, produces incisors with grooved enamel surfaces that exhibit the same molecular characteristics as the tips of molar cusps. Mice with a null mutation of Lrp4 develop extra cusps on molars and have incisors that exhibit clear molar-like cusp and root morphologies. Molecular analysis identifies misregulation of Shh and Bmp signaling in the mutant incisors and suggests an uncoupling of the processes of tooth shape determination and morphogenesis. Incisors thus possess a developmentally suppressed, cuspid crown-like morphogenesis program similar to that in molars that is revealed by loss of Lrp4 activity. Several mammalian species naturally possess multicuspid incisors, suggesting that mammals have the capacity to form multicuspid teeth regardless of location in the oral jaw. Localized loss of enamel may thus have been an intermediary step in the evolution of cusps, both of which use Lrp4-mediated signaling.
机译：牙齿形状的改变在脊椎动物进化中起着重要作用，其牙列的改变使生物体能够适应新的喂养策略。当前的观点是，磨牙从简单的圆锥形牙齿（类似于犬齿）演变而来，逐渐增加了额外的“圆锥”以形成逐渐复杂的多尖牙冠。然而，哺乳动物的门牙既不是圆锥形的也不是多齿的，它们的演变还不清楚。我们表明，细胞表面受体Lrp4的亚型突变，它调节多个信号通路，产生带有凹槽的釉质表面的切牙，这些釉质表现出与磨牙尖的尖端相同的分子特征。 Lrp4无效突变的小鼠在臼齿上会形成额外的尖齿，并具有切齿，这些切齿显示出清晰的臼齿样尖齿和根部形态。分子分析确定了突变型切牙中Shh和Bmp信号的失调，并暗示了牙齿形状确定和形态发生过程的解耦。因此，门牙具有发育抑制的，尖锐的冠状样形态发生程序，类似于在臼齿中通过Lrp4活性降低所揭示的形态形成程序。几种哺乳动物自然拥有多尖齿门齿，这表明哺乳动物具有形成多尖齿的能力，而无论其在口腔颌中的位置如何。因此，牙釉质的局部丢失可能是牙尖演变的中间步骤，两者都使用Lrp4介导的信号传导。

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    Atsushi Ohazama; James Blackburn; Thantrira Porntaveetus; Masato S. Ota; Hong Y. Choi; Eric B. Johnson; Philip Myers; Shelly Oommen; Kazuhiro Eto; John A. Kessler; Takashi Kondo; Gareth J. Fraser; J. Todd Streelman; Ulyses F. J. Pardinas; Abigail S. Tucker; Pablo E. Ortiz; Cyril Charles; Laurent Viriot; Joachim Herz; Paul T. Sharpe;

  • 作者单位

    Department of Craniofacial Development, Dental Institute, King's College London, Guy's Hospital, London SE1 9RT, United Kingdom;

    Department of Craniofacial Development, Dental Institute, King's College London, Guy's Hospital, London SE1 9RT, United Kingdom;

    Department of Craniofacial Development, Dental Institute, King's College London, Guy's Hospital, London SE1 9RT, United Kingdom;

    Section of Molecular Craniofacial Embryology, Graduate School, Tokyo Medical and Dental University, Tokyo 113-8549, Japan;

    Department of Molecular Genetics, University of Texas Southwestern Medical Center, Dallas, TX 75390-9046;

    Department of Molecular Genetics, University of Texas Southwestern Medical Center, Dallas, TX 75390-9046;

    Department of Ecology and Evolutionary Biology, Museum of Zoology, University of Michigan, Ann Arbor, MI 48109-1079;

    Department of Craniofacial Development, Dental Institute, King's College London, Guy's Hospital, London SE1 9RT, United Kingdom;

    Section of Molecular Craniofacial Embryology, Graduate School, Tokyo Medical and Dental University, Tokyo 113-8549, Japan;

    Department of Neurology, Northwestern University Feinberg School of Medicine, Chicago, IL 60611;

    Kondo Research Unit, Neuro-Developmental Disorder Research Group, Brain Science Institute, Institute of Physical and Chemical Research (RIKEN), Wako, Saitama 351-0198, Japan;

    School of Biology, Georgia Institute of Technology, Atlanta, GA 30332;

    School of Biology, Georgia Institute of Technology, Atlanta, GA 30332;

    Centro Nacional Patagonico, 9120 Puerto Madryn, Chubut, Argentina;

    Department of Craniofacial Development, Dental Institute, King's College London, Guy's Hospital, London SE1 9RT, United Kingdom;

    Consejo Nacional de Investigaciones Cientificas y Tecnicas de Argentina, Catedra de Paleontologia, Facultad de Ciencias Naturales e Instituto Miguel Lillo, Universidad Nacional de Tucuman, Miguel Lillo 205 4000-San Miguel de Tucuman, Argentina;

    Department of Orofacial Sciences, University of California, San Francisco, CA 94143-0442;

    Team ?Evo-Devo of Vertebrate Dentitions, Institute of Functional Genomics of Lyon, Universite de Lyon, Centre National de la Recherche Scientifique, Institut National de la Recherche Agronomique, 69364 Lyon Cedex 07, France;

    Department of Molecular Genetics, University of Texas Southwestern Medical Center, Dallas, TX 75390-9046;

    Department of Craniofacial Development, Dental Institute, King's College London, Guy's Hospital, London SE1 9RT, United Kingdom;

  • 收录信息 美国《科学引文索引》(SCI);美国《生物学医学文摘》(MEDLINE);美国《化学文摘》(CA);
  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类
  • 关键词

    cusp; Lrp4; tooth development; evo/devo; multicuspid crown;

    机译：尖尖Lrp4;牙齿发育;evo / devo;多尖牙冠;

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