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首页> 外文期刊>Proceedings of the National Academy of Sciences of the United States of America >Foxp~(3+) CD25~+ regulatory T cells specific for a neo-self-antigen develop at the double-positive thymic stage
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Foxp~(3+) CD25~+ regulatory T cells specific for a neo-self-antigen develop at the double-positive thymic stage

机译：对新自身抗原特异的Foxp〜（3+）CD25〜+调节性T细胞在双阳性胸腺阶段发育

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摘要

Thymus-derived regulatory T cells (Tregs) expressing CD4, CD25, and the transcription factor Foxp3 play major roles in preventing autoimmunity. The Treg population is enriched in T cells expressing high-avidity self-reactive T cell receptors, and thymic epithelial cells expressing self-antigens (Ag) have been implicated in their induction and/or selection. However, the thymic selection events leading to Treg lineage commitment remain unclear. We followed the thymic development of self-Ag-specific Tregs in double-transgenic mice coexpressing a neo-self-Ag, hemagglutinin (HA) under the control of a neural tissue-specific promoter, and a transgenic class Ⅱ-restricted T cell antigen receptor specific for HA111-119. Our data show that the promiscuous expression of the HA transgene in thymic epithelial cells is involved in the selective induction and/or expansion of HA-specific Foxp3~+ Treg thymic precursors as early as the double-positive stage.
机译：表达CD4，CD25和转录因子Foxp3的胸腺衍生调节性T细胞（Treg）在预防自身免疫中起主要作用。 Treg群体富含表达高亲和力自我反应性T细胞受体的T细胞，并且表达自身抗原（Ag）的胸腺上皮细胞也参与了它们的诱导和/或选择。然而，胸腺选择事件导致Treg谱系承诺仍不清楚。我们跟踪了在双神经元特异性启动子和转基因Ⅱ类限制性T细胞抗原控制下共表达新自我抗原，血凝素（HA）的双转基因小鼠中胸腺抗原的自身抗原调节HA111-119特有的受体。我们的数据表明，HA转基因在胸腺上皮细胞中的混杂表达早在双阳性阶段就参与了HA特异性Foxp3〜+ Treg胸腺前体的选择性诱导和/或扩增。

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