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首页> 外文期刊>Proceedings of the National Academy of Sciences of the United States of America >Two-component signaling provides the major output from the cyanobacterial circadian clock
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Two-component signaling provides the major output from the cyanobacterial circadian clock

机译：两成分信号提供了蓝藻生物钟的主要输出

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摘要

Biological processes occur in a temporal context, and the coordination of these processes with one another and with the external environmental cycle is critical for organismal fitness. Circadian rhythms, endogenous rhythms with periods of ≈ 24 h, have been described in almost all organisms, from bacteria to humans. An internal biological circadian clock controls many processes, notably the temporal expression of many genes. A substantial portion of the transcrip-tome is clock-regulated in fungi, plants, and animals (for examples, see refs.2-4). In the most extreme example, Syn-echococcus elongatus PCC 7942, transcription rates of the entire genome are circadian-regulated. How might signals from a central oscillator be transduced into circadian transcription? In this issue of PNAS, Takai et al. describe a histidine kinase/response regulator two-component module that transduces a signal emanating from the circadian clock to generate genome-wide oscillations in transcription.
机译：生物过程发生在时间上，并且这些过程之间以及与外部环境循环之间的协调对于有机体适应至关重要。昼夜节律是周期约为24小时的内源性节律，在从细菌到人类的几乎所有生物中都有描述。内部生物生物钟控制许多过程，尤其是许多基因的时间表达。转录，的很大一部分在真菌，植物和动物中受到时钟调节（例如，参见参考2-4）。在最极端的例子中，伸长的Sy-echococcus elongatus PCC 7942，整个基因组的转录速率是昼夜调节的。来自中央振荡器的信号如何转换为昼夜节律转录？在本期的PNAS中，Takai等人。描述了组氨酸激酶/应答调节剂两组分模块，该模块转导昼夜节律时钟发出的信号以产生转录过程中的全基因组振荡。

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