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首页> 外文期刊>Proceedings of the National Academy of Sciences of the United States of America >Differential dependence of CD4(+)CD25(+) regulatory and natural killer-like T cells on signals leading to NF-kappa B activation
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Differential dependence of CD4(+)CD25(+) regulatory and natural killer-like T cells on signals leading to NF-kappa B activation

机译：CD4（+）CD25（+）调节性和天然杀伤性T细胞对导致NF-κB活化的信号的差异依赖性

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摘要

Natural killer-like (NK) T, regulatory T (T-R) and memory type T cells display surface phenotypes reminiscent of activated T cells. Previously, we reported that the generation of T-R cells and, to a lesser extent, of memory type T cells, depends on IkappaB kinase 2. Here, we show that T cell-specific ablation of IkappaB kinase 2, in addition, completely precludes NKT cell development. T cell antigen receptor (TCR)-induced signals to activate NF-kappaB are essential for mature T cell activation, leading us to hypothesize that this pathway could play an important role in the generation of the antigen-driven T cell subsets comprising T-R, memory type T, and NKT cells. TCR-mediated NF-kappaB activation critically depends on Bcl10 and PKCtheta. By using mice deficient for these proteins, we demonstrate that the generation of T-R and, to a lesser extent, of memory type T cells, depends on Bcl10 and PKCtheta, and therefore, most likely on NF-kappaB activation initiated by TCR engagement. NKT cells, on the other hand, require PKCtheta for thymic development, whereas absence of Bcl10 leads primarily to the reduction of peripheral NKT cell numbers. [References: 47]
机译：天然杀手样（NK）T，调节性T（T-R）和记忆型T细胞表现出令人联想起活化T细胞的表面表型。以前，我们报道了TR细胞的生成以及较小程度的记忆型T细胞的依赖于IkappaB激酶2。在这里，我们证明了IkappaB激酶2的T细胞特异性消融完全排除了NKT细胞发育。 T细胞抗原受体（TCR）诱导的激活NF-κB的信号对于成熟T细胞激活必不可少，这使我们推测该途径可能在抗原驱动的T细胞亚群（包括TR，记忆）的产生中起重要作用T型和NKT细胞TCR介导的NF-κB活化关键取决于Bcl10和PKCtheta。通过使用缺乏这些蛋白质的小鼠，我们证明了T-R的生成以及较小程度的记忆型T细胞的生成取决于Bcl10和PKCtheta，因此最有可能取决于TCR参与引发的NF-κB活化。另一方面，NKT细胞需要PKCtheta进行胸腺发育，而缺少Bcl10则主要导致外周NKT细胞数量减少。 [参考：47]

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