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首页> 外文期刊>Proceedings of the National Academy of Sciences of the United States of America >Expression of T cell receptor β locus in central nervous system neurons
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Expression of T cell receptor β locus in central nervous system neurons

机译：T细胞受体β基因座在中枢神经系统神经元中的表达

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摘要

MHC class I proteins are cell-surface ligands that bind to T cell receptors and other immunoreceptors and act to regulate the activation state of immune cells. Recent work has shown that MHC class I genes and CD3ζ, an obligate component of T cell receptors, are expressed in neurons, are regulated by neuronal activity, and function in neuronal development and plasticity. A search for additional neuronally expressed T cell receptor components has revealed that the T cell antigen receptor β (TCR?) locus is expressed in neurons of the murine central nervous system and that this expression is dynamically regulated over development. In neonates, expression is most abundant in various thalamic nuclei. At later ages and in adults, thalamic expression fades and cortical expression is robust, particularly in layer 6. In T cells, protein-encoding transcripts are produced only after recombination of the TCRβ genomic locus, which joins variable, diversity, and joining regions, a process that creates much of the diversity of the immune system. We detect no genomic recombination in neurons. Rather, transcripts begin in regions upstream of several joining regions, and are spliced to constant region segments. One of the transcripts encodes a hypothetical 207-aa, 23-kDa protein, which includes the TCRβ J2.7 region, and the entire C region. These observations suggest that TCRβ may function in neurons.
机译：MHC I类蛋白是与T细胞受体和其他免疫受体结合的细胞表面配体，并起着调节免疫细胞激活状态的作用。最近的研究表明，MHC I类基因和CD3ζ（T细胞受体的主要组成部分）在神经元中表达，受神经元活性调节，并在神经元发育和可塑性中起作用。对其他神经元表达的T细胞受体成分的研究表明，在鼠中枢神经系统的神经元中表达了T细胞抗原受体β（TCR 4）基因座，并且该表达在发育过程中受到动态调节。在新生儿中，各种丘脑核中的表达最丰富。在较晚的年龄和成年人中，丘脑表达减弱，而皮质表达则很强健，尤其是在第6层。在T细胞中，仅在TCRβ基因组座位重组后才产生蛋白质编码的转录本，该基因组连接可变区，多样性区和连接区，产生免疫系统多样性的过程。我们没有检测到神经元中的基因组重组。而是，转录本开始于几个连接区域上游的区域，并剪接至恒定区片段。转录物之一编码一种假定的207-aa，23-kDa蛋白，其中包括TCRβJ2.7区和整个C区。这些观察结果提示TCRβ可能在神经元中起作用。

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