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Corpus callosum areas in first-episode patients with bipolar disorder

机译：双相情感障碍首发患者的call体区域

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Background. Morphological changes in the corpus callosum (CC) have been described in bipolar disorder, but with inconsistencies among the reports. We investigated the CC areas by magnetic resonance imaging (MRI) in 12 first-episode patients with bipolar disorder and 12 controls. Method. Twelve medication-naive patients with bipolar I disorder (six males, six females; aged 28.2 ± 6.5 years) with manic or mixed episodes and 12 age- and gender-matched healthy controls (six males, six females; aged 26.8 ± 7.6 years) were recruited to the study. MRI scans was obtained using a 1.5-T GE Signa Excite high-speed scanner. Anatomical measurements were conducted on a computer workstation with the software Scion Image Beta-3b for Windows. Statistical analysis was performed using an analysis of covariance (ANCOVA), the t test, χ~2 and partial correlation analyses. Results. Bipolar patients had significantly smaller areas of total CC, anterior body posterior body and isthmus compared with healthy control subjects by ANCOVA, with age, gender and intra-cranial volume (ICV) as covariates. There was a negative correlation between total CC, posterior body and isthmus areas and Young Mania Rating Scale (YMRS) scores. Conclusion. The findings suggest that CC morphology may be associated with the pathophysiology of bipolar disorder.
机译：背景。在双相情感障碍中已描述了call体（CC）的形态变化，但报告之间存在不一致之处。我们通过磁共振成像（MRI）在12例双相情感障碍首发患者和12例对照中调查了CC区域。方法。 12名未接受药物治疗的双相I型障碍患者（男6例，女6例；年龄28.2±6.5岁），有躁狂发作或混合发作，以及12名年龄和性别匹配的健康对照组（男6例，女6例；年龄26.8±7.6岁）被招募到研究中。使用1.5-T GE Signa Excite高速扫描仪进行MRI扫描。解剖测量是在计算机工作站上使用Windows版Scion Image Beta-3b软件进行的。使用协方差分析（ANCOVA），t检验，χ〜2和偏相关分析进行统计分析。结果。双相情感障碍患者的总CC，前身后体和峡部面积明显小于健康对照受试者的ANCOVA，年龄，性别和颅内体积（ICV）为协变量。总CC，后身和峡部面积与青年躁狂症评分量表（YMRS）得分之间呈负相关。结论。这些发现提示CC形态可能与躁郁症的病理生理有关。

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