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Relevance of vitamin D in muscle health

机译:维生素D在肌肉健康中的相关性

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This review will summarize the impact of vitamin D deficiency on muscle health. Mechanistic evidence regarding the presence of the specific vitamin D receptor in muscle tissue and muscle biopsy abnormalities observed with deficiency will be reviewed, as well as molecular and non-molecular effects of vitamin D in muscle tissue. At the clinical level, the evidence from randomized controlled trials of vitamin D supplementation on functional improvement and fall reduction will be summarized. Further, the manuscript will discuss whether vitamin D effects on fall prevention modulate in part its benefit on fracture prevention and why fall prevention is essential in fracture prevention at higher age. Finally, trial and epidemiological data will be reviewed to assess desirable serum 25-hydroxyvitamin D levels for optimal muscle health.
机译:这篇综述将总结维生素D缺乏对肌肉健康的影响。将审查有关在肌肉组织中存在特定维生素D受体和观察到缺乏的肌肉活检异常的力学证据,以及维生素D在肌肉组织中的分子和非分子作用。在临床上,将总结补充维生素D改善功能和减少跌倒的随机对照试验的证据。此外,手稿还将讨论维生素D对预防跌倒的作用是否会部分调节其对预防骨折的益处,以及为什么预防跌倒对于高龄骨折的预防至关重要。最后,将审查试验和流行病学数据,以评估理想的血清25-羟基维生素D水平,以获得最佳的肌肉健康。

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